发明授权
- 专利标题： Topoisomerase I
- 专利标题（中）： 拓扑异构酶I
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申请号： US946475申请日： 1997-10-07
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公开(公告)号： US6013505A公开(公告)日： 2000-01-11
- 发明人: Michael N. Gwynn , Howard Kallendar , Leslie M. Palmer
- 申请人： Michael N. Gwynn , Howard Kallendar , Leslie M. Palmer
- 申请人地址： PA Philadelphia
- 专利权人： SmithKline Beecham Corporation
- 当前专利权人： SmithKline Beecham Corporation
- 当前专利权人地址： PA Philadelphia
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K38/00 ; A61K38/45 ; A61K38/55 ; A61K39/00 ; A61K48/00 ; A61P31/04 ; C07K14/81 ; C12N5/00 ; C12N5/10 ; C12N9/90 ; C12N15/09 ; C12N15/61 ; C12P21/08 ; C12Q1/68 ; C12R1/91 ; G01N33/531 ; G01N33/566 ; C07H21/04
摘要：
Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
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