发明授权
- 专利标题: Nucleic acid ligands that bind to and inhibit DNA polymerases
- 专利标题(中): 结合并抑制DNA聚合酶的核酸配体
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申请号: US945734申请日: 1997-10-28
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公开(公告)号: US6020130A公开(公告)日: 2000-02-01
- 发明人: Larry Gold , Sumedha Javasena
- 申请人: Larry Gold , Sumedha Javasena
- 申请人地址: CO Boulder
- 专利权人: NeXstar Pharmaceuticals, Inc.
- 当前专利权人: NeXstar Pharmaceuticals, Inc.
- 当前专利权人地址: CO Boulder
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; C12Q1/68 ; C12P1/68 ; C07H21/02 ; C07H21/04 ; C12Q19/34
摘要:
This invention discloses high-affinity oligonucleotide ligands to the thermostable Taq polymerase and Tth polymerase. Specifically, this invention discloses DNA ligands having the ability to bind to the Taq and Tth polymerases and the methods for obtaining such ligands. The ligands are capable of inhibiting polymerases at ambient temperatures.
公开/授权文献
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