发明授权
US6022899A Substituted benzyloxy-carbonylguanidines, a process for their
preparation, their use as a medicament or diagnostic, and a medicament
containing them
失效
取代的苄氧基 - 羰基胍，其制备方法，它们作为药物或诊断剂的用途，以及含有它们的药物
- 专利标题： Substituted benzyloxy-carbonylguanidines, a process for their preparation, their use as a medicament or diagnostic, and a medicament containing them
- 专利标题（中）： 取代的苄氧基 - 羰基胍，其制备方法，它们作为药物或诊断剂的用途，以及含有它们的药物
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申请号： US5163申请日： 1998-01-09
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公开(公告)号： US6022899A公开(公告)日： 2000-02-08
- 发明人: Heinz-Werner Kleemann , Joachim Brendel , Jan-Robert Schwark , Andreas Weichert , Hans-Jochen Lang , Udo Albus , Wolfgang Scholz
- 申请人： Heinz-Werner Kleemann , Joachim Brendel , Jan-Robert Schwark , Andreas Weichert , Hans-Jochen Lang , Udo Albus , Wolfgang Scholz
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： DEX19518073 19950517
- 主分类号： C07D215/20
- IPC分类号： C07D215/20 ; A61K9/06 ; A61K9/10 ; A61K31/155 ; A61K31/17 ; A61K31/175 ; A61K31/18 ; A61K31/27 ; A61K31/275 ; A61K31/44 ; A61K31/4406 ; A61K31/4418 ; A61K31/47 ; A61K31/475 ; A61K35/00 ; A61P1/16 ; A61P3/08 ; A61P9/00 ; A61P9/06 ; A61P9/08 ; A61P9/10 ; A61P13/02 ; A61P15/00 ; A61P35/00 ; A61P43/00 ; C07C279/10 ; C07C279/24 ; C07C317/22 ; C07C317/32 ; C07C317/46 ; C07D213/30 ; C07D215/14 ; G01N33/574 ; G01N33/94 ; C07C275/04
摘要：
There are described compounds of the formula I ##STR1## in which the substituents R(1) to R(7) and X have the meanings shown in the claims, and their pharmaceutically tolerable salts. These are effective inhibitors of the cellular sodium proton antiporter (Na.sup.+ /H.sup.+ exchanger). They are therefore outstandingly suitable for the treatment of all diseases which can be attributed to increased Na.sup.+ /H.sup.+ exchange.
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