Invention Grant
- Patent Title: Method for treating tumors using 2-aryl-naphthyridin-4-ones
- Patent Title (中): 使用2-芳基 - 萘啶-4-酮治疗肿瘤的方法
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Application No.: US363101Application Date: 1999-07-29
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Publication No.: US6071930APublication Date: 2000-06-06
- Inventor: Kuo-Hsiung Lee , Ke Chen , Sheng-Chu Kuo
- Applicant: Kuo-Hsiung Lee , Ke Chen , Sheng-Chu Kuo
- Applicant Address: NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: NC Chapel Hill
- Main IPC: A61K31/4375
- IPC: A61K31/4375 ; A61P17/06 ; A61P19/06 ; A61P35/00 ; A61P43/00 ; C07D213/74 ; C07D471/04
Abstract:
The present invention provides compounds of Formula I: ##STR1## wherein A and R.sub.1 -R.sub.8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psoriasis, gout, papiloma, warts, and a variety of tumors.
Public/Granted literature
- USD314408S Toy block vehicle Public/Granted day:1991-02-05
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