发明授权
- 专利标题： Process for chromatographic separation of peptides and nucleic acid, and new high affinity ion exchange matrix
- 专利标题（中）： 肽和核酸的色谱分离方法，以及新的高亲和力离子交换矩阵
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申请号： US117678申请日： 1998-12-29
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公开(公告)号： US6090288A公开(公告)日： 2000-07-18
- 发明人: Rolf Berglund , Jan Bergstrom , Makonnen Belew , Lennart Soderberg
- 申请人： Rolf Berglund , Jan Bergstrom , Makonnen Belew , Lennart Soderberg
- 申请人地址： SEX Uppsala
- 专利权人： Amersham Pharmacia Biotech AB
- 当前专利权人： Amersham Pharmacia Biotech AB
- 当前专利权人地址： SEX Uppsala
- 优先权： SEX9600590 19960219
- 主分类号： B01D15/08
- IPC分类号： B01D15/08 ; B01D15/36 ; B01J41/20 ; C07K1/18
摘要：
Process for separating off a peptide or a nucleic acid by an anion exchanger (I) characterized in that a) the anion exchanger (I) exhibits ligands, which (i) contain a primary, secondary or tertiary amino group and (ii) are covalently bound to an organic polymer (matrix), b) there on a carbon atom at a distance of 2 or 3 atoms away from an amino nitrogen in the ligands is a hydroxyl group or a primary, secondary or tertiary amino group, and c) the maximum elution ionic strength in the pH range 2-14 for at least one of the proteins transferrin, ovalbumin 1, ovalbumin 2, .beta.-lactoglobulin 1 and .beta.-lactoglobulin 2 on the anion exchanger is higher than the elution ionic strength required for a quaternary comparative ion exchanger.
公开/授权文献
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