发明授权
US6103224A N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof
失效
N NABLA 2 CSF-1（短型）及其羧基截短的片段
- 专利标题： N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof
- 专利标题（中）： N NABLA 2 CSF-1（短型）及其羧基截短的片段
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申请号： US426570申请日： 1995-04-21
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公开(公告)号： US6103224A公开(公告)日： 2000-08-15
- 发明人: Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
- 申请人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
- 申请人地址： CA Emeryville
- 专利权人： Chiron Corporation
- 当前专利权人： Chiron Corporation
- 当前专利权人地址： CA Emeryville
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/53 ; C12N1/21 ; C12N15/27 ; C12N15/73 ; A61K38/19 ; A61K38/20
摘要：
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
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