发明授权
US6124291A Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
失效
吡咯并[1,2-a]吡嗪-1,4-二酮丝氨酸蛋白酶抑制剂
- 专利标题： Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
- 专利标题（中）： 吡咯并[1,2-a]吡嗪-1,4-二酮丝氨酸蛋白酶抑制剂
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申请号： US171863申请日： 1998-10-27
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公开(公告)号： US6124291A公开(公告)日： 2000-09-26
- 发明人: Kent A. Berryman , Annette M. Doherty , Jeremy J. Edmunds , M. Arshad Siddiqui
- 申请人： Kent A. Berryman , Annette M. Doherty , Jeremy J. Edmunds , M. Arshad Siddiqui
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D401/12 ; A61K31/498 ; C07D241/38 ; C07D403/12
摘要：
This invention relates to pyrrolo[1,2-a]pyrazine-1,4-diones of general formula: ##STR1## wherein B is carbonyl or methylene, R.sup.2, R.sup.4, R.sup.5, and R.sup.6 are hydrogen, alkyl, or substituted alkyl, A is a basic group, and Q is hydrogen or a keto heterocycle group.The compounds are inhibitors of serine proteases, typically thrombin, Factor Xa, and Factor VIIa, and are useful for treating and preventing thrombotic disorders.
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