发明授权
US6124317A 2-substituted piperidine analogs and their use as subtype-selective NMDA
receptor antagonists
失效
2-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途
- 专利标题： 2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists
- 专利标题（中）： 2-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途
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申请号： US91593申请日： 1998-11-18
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公开(公告)号： US6124317A公开(公告)日： 2000-09-26
- 发明人: Christopher F. Bigge , John F. W. Keana , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Anthony P. Guzikowski
- 申请人： Christopher F. Bigge , John F. W. Keana , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Anthony P. Guzikowski
- 申请人地址： NJ Morris Plains CA Irvine
- 专利权人： Warner-Lambert Company,Cocensys, Inc.
- 当前专利权人： Warner-Lambert Company,Cocensys, Inc.
- 当前专利权人地址： NJ Morris Plains CA Irvine
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/454 ; C07D211/14 ; C07D401/12 ; A01N43/40
摘要：
Novel 2-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 2-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartatc (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, amioglycoside antibiotics-induced hearing loss, migraine headaches, chronic pain, glaucoma, CMV retinitis, psychosis, urinary incontinence, opioid tolerance or withdrawal, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.
公开/授权文献
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