发明授权
US6153430A Nucleic acid encoding mesothelin, a differentiation antigen present on
mesothelium, mesotheliomas and ovarian cancers
失效
编码间皮素的核酸，存在于间皮上的分化抗原，间皮瘤和卵巢癌
- 专利标题： Nucleic acid encoding mesothelin, a differentiation antigen present on mesothelium, mesotheliomas and ovarian cancers
- 专利标题（中）： 编码间皮素的核酸，存在于间皮上的分化抗原，间皮瘤和卵巢癌
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申请号： US215035申请日： 1998-12-17
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公开(公告)号： US6153430A公开(公告)日： 2000-11-28
- 发明人: Ira Pastan , Kai Chang
- 申请人： Ira Pastan , Kai Chang
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/00 ; A61K31/70 ; A61K31/7088 ; A61K39/395 ; A61K45/00 ; A61K47/48 ; A61K49/00 ; A61K51/00 ; A61K51/10 ; A61P35/00 ; C07K14/195 ; C07K16/30 ; C07K19/00 ; C12N5/20 ; C12Q1/68 ; G01N33/15 ; G01N33/53 ; G01N33/574 ; C12N5/16 ; C07H21/02 ; C07H21/04 ; C12N15/79
摘要：
This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting and/or inhibiting the growth of cells bearing mesothelin, methods for detecting the antigen and its expression level as an indication of the presence of tumor cells, and kits for such detection.
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