发明授权
- 专利标题: Oxazolidinones as .alpha..sub.1A receptor antagonists
- 专利标题(中): 恶唑烷酮作为α1A受体拮抗剂
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申请号: US99225申请日: 1998-06-17
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公开(公告)号: US6159990A公开(公告)日: 2000-12-12
- 发明人: Bharat Lagu , T.G. Murali Dhar , Dhanapalan Nagarathnam , Yoon T. Jeon , Mohammad R. Marzabadi , Wai C. Wong , Charles Gluchowski
- 申请人: Bharat Lagu , T.G. Murali Dhar , Dhanapalan Nagarathnam , Yoon T. Jeon , Mohammad R. Marzabadi , Wai C. Wong , Charles Gluchowski
- 申请人地址: NJ Paramus
- 专利权人: Synaptic Pharmaceutical Corporation
- 当前专利权人: Synaptic Pharmaceutical Corporation
- 当前专利权人地址: NJ Paramus
- 主分类号: A61K31/58
- IPC分类号: A61K31/58 ; C07D263/26 ; C07D263/52 ; C07D401/12 ; C07D401/14 ; C07D413/12 ; C07D413/14 ; A61K31/445
摘要:
This invention is directed to oxazolidinone compounds which are selective antagonists for human .alpha..sub.1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the .alpha..sub.1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
公开/授权文献
- USD413833S Pumpkin figure 公开/授权日:1999-09-14