发明授权
US06183951B2 Methods of diagnosing clinical subtypes of crohn's disease with characteristic responsiveness to anti-Th1 cytokine therapy
失效
诊断克罗恩病临床亚型的方法具有抗Th1细胞因子治疗的特征反应
- 专利标题： Methods of diagnosing clinical subtypes of crohn's disease with characteristic responsiveness to anti-Th1 cytokine therapy
- 专利标题（中）： 诊断克罗恩病临床亚型的方法具有抗Th1细胞因子治疗的特征反应
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申请号： US08855825申请日： 1997-05-12
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公开(公告)号： US06183951B2公开(公告)日： 2001-02-06
- 发明人: Scott E. Plevy , Stephan R. Targan , Kent Taylor , Mary J. Barry
- 申请人： Scott E. Plevy , Stephan R. Targan , Kent Taylor , Mary J. Barry
- 主分类号： C12Q168
- IPC分类号： C12Q168
摘要：
The present invention provides methods based on serological and genetic markers for diagnosing clinical subtypes of Crohn's disease (CD) having characteristic responsiveness to anti-Th1 cytokine therapy. In the methods of the inventions the presence of perinuclear anti-neutrophil antibody (pANCA), the presence of the TNFa10b4c1d3e3 haplotype or the presence TNFa11b4c1d3e3 haplotype each are independently diagnostic of a clinical subtype of CD having an inferior clinical response to anti-Th1 cytokine therapy. In addition, the presence of the homozygous TNF-&bgr; 1111 haplotype involving the TNFc, aa13L, aa26 and NcoI loci is independently diagnostic of a clinical subtype of CD having an inferior clinical response to anti-Th1 cytokine therapy. The presence of speckling anti-pan polymorphonuclear antibody (SAPPA) is diagnostic of a clinical subtype of CD having a superior clinical response to anti-Th1 cytokine therapy.
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