发明授权
- 专利标题： Antisense modulation of human mdm2 expression
- 专利标题（中）： 人mdm2表达的反义调制
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申请号： US09280805申请日： 1999-03-26
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公开(公告)号： US06184212B2公开(公告)日： 2001-02-06
- 发明人: Loren J. Miraglia , Pamela Nero , Mark J. Graham , Brett P. Monia , Lex M. Cowsert
- 申请人： Loren J. Miraglia , Pamela Nero , Mark J. Graham , Brett P. Monia , Lex M. Cowsert
- 主分类号： C07H2104
- IPC分类号： C07H2104
摘要：
Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
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