公开(公告)号：US20060019920A1

公开(公告)日：2006-01-26

申请号：US11179128

申请日：2005-07-11

申请人： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

发明人： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N9/1205 ,  Y02P20/582

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.

公开(公告)号：US20050222073A1

公开(公告)日：2005-10-06

申请号：US11071724

申请日：2005-03-02

申请人： C. Bennett ,  Brett Monia ,  Rosanne Crooke ,  Mark Graham ,  Susan Freier ,  Pamela Nero ,  Edward Wancewicz ,  Nicholas Dean ,  Lex Cowsert ,  Kenneth Dobie

发明人： C. Bennett ,  Brett Monia ,  Rosanne Crooke ,  Mark Graham ,  Susan Freier ,  Pamela Nero ,  Edward Wancewicz ,  Nicholas Dean ,  Lex Cowsert ,  Kenneth Dobie

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节甲状腺激素受体相互作用体6的表达。该组合物包含靶向编码甲状腺激素受体相互作用核酸的反义化合物，特别是反义寡核苷酸。6.使用这些化合物调节甲状腺激素的方法 受体相互作用6表达和用于治疗与甲状腺激素受体相互作用者6的表达相关的疾病。

公开(公告)号：US20050137160A1

公开(公告)日：2005-06-23

申请号：US11031827

申请日：2005-01-07

申请人： Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Edward Wancewicz

发明人： Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Edward Wancewicz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of cholesteryl ester transfer protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cholesteryl ester transfer protein. Methods of using these compounds for modulation of cholesteryl ester transfer protein expression and for treatment of diseases associated with expression of cholesteryl ester transfer protein are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节胆固醇酯转移蛋白的表达。 组合物包含靶向编码胆固醇酯转移蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节胆固醇酯转移蛋白表达和治疗与胆固醇酯转移蛋白的表达相关的疾病的方法。

公开(公告)号：US06184212B2

公开(公告)日：2001-02-06

申请号：US09280805

申请日：1999-03-26

申请人： Loren J. Miraglia ,  Pamela Nero ,  Mark J. Graham ,  Brett P. Monia ,  Lex M. Cowsert

发明人： Loren J. Miraglia ,  Pamela Nero ,  Mark J. Graham ,  Brett P. Monia ,  Lex M. Cowsert

IPC分类号： C07H2104

CPC分类号： C12N15/113 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/335 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525 ,  C12N2310/3521

摘要： Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.

摘要翻译： 提供化合物，组合物和方法用于抑制人mdm2的表达。 组合物包括靶向编码mdm2的核酸的反义化合物。 提供了使用这些寡核苷酸抑制mdm2表达和治疗诸如与mdm2过度表达相关的癌症的疾病的方法。

公开(公告)号：US06809193B2

公开(公告)日：2004-10-26

申请号：US09774809

申请日：2001-01-31

申请人： Robert McKay ,  Nicholas M. Dean ,  Brett P. Monia ,  Pamela Nero ,  William A. Gaarde

发明人： Robert McKay ,  Nicholas M. Dean ,  Brett P. Monia ,  Pamela Nero ,  William A. Gaarde

IPC分类号： C12N1585

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/334 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12N2310/3525

摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.

摘要翻译： 提供了通过调节编码JunN末端激酶（JNK蛋白）的基因的表达进行治疗的疾病或病症的治疗和诊断的组合物和方法。 本文提供了与编码JNK1，JNK2和JNK3的核酸以及其它JNK蛋白及其特异性同种型特异性杂交的寡核苷酸。 还提供了通过用这种寡核苷酸调节一种或多种JNK蛋白质的表达来治疗患有治疗性干预的疾病或障碍的动物的方法。 还提供了用于治疗和诊断与一种或多种JNK蛋白异常表达相关的疾病或病症的方法。 还提供了用于诱导凋亡和用于治疗与凋亡降低相关的疾病或病症的方法。

公开(公告)号：US20120022133A1

公开(公告)日：2012-01-26

申请号：US13082111

申请日：2011-04-07

申请人： Rosanne M. Crooke ,  Mark J. Graham ,  Pamela Nero ,  Edward Wancewicz

发明人： Rosanne M. Crooke ,  Mark J. Graham ,  Pamela Nero ,  Edward Wancewicz

IPC分类号： A61K31/7088 ,  C12N5/071 ,  A61P3/06 ,  A61P9/00 ,  A61P3/00 ,  C12N15/113 ,  A61P9/10

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of cholesteryl ester transfer protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cholesteryl ester transfer protein. Methods of using these compounds for modulation of cholesteryl ester transfer protein expression and for treatment of diseases associated with expression of cholesteryl ester transfer protein are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节胆固醇酯转移蛋白的表达。 组合物包含靶向编码胆固醇酯转移蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节胆固醇酯转移蛋白表达和治疗与胆固醇酯转移蛋白的表达相关的疾病的方法。

公开(公告)号：US20050267063A1

公开(公告)日：2005-12-01

申请号：US11117013

申请日：2005-04-27

申请人： C. Bennett ,  Brett Monia ,  Susan Freier ,  Brenda Baker ,  William Gaarde ,  Erich Koller ,  Susan Murray ,  Andrew Watt ,  Jacqueline Wyatt ,  Pamela Nero ,  Mark Roach ,  Lex Cowsert ,  Kenneth Dobie

发明人： C. Bennett ,  Brett Monia ,  Susan Freier ,  Brenda Baker ,  William Gaarde ,  Erich Koller ,  Susan Murray ,  Andrew Watt ,  Jacqueline Wyatt ,  Pamela Nero ,  Mark Roach ,  Lex Cowsert ,  Kenneth Dobie

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C12N5/02 ,  C12N15/113 ,  C12N15/85

CPC分类号： C12N15/1137 ,  A61K38/00 ,  B23Q2011/0808 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of p70 S6 kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding p70 S6 kinase. Methods of using these compounds for modulation of p70 S6 kinase expression and for treatment of diseases associated with expression of p70 S6 kinase are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节p70 S6激酶的表达。 组合物包含靶向编码p70 S6激酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节p70 S6激酶表达和治疗与p70 S6激酶表达相关的疾病的方法。

公开(公告)号：US06448079B1

公开(公告)日：2002-09-10

申请号：US09640101

申请日：2000-08-15

申请人： Brett P. Monia ,  William A. Gaarde ,  Pamela Nero ,  Robert McKay

发明人： Brett P. Monia ,  William A. Gaarde ,  Pamela Nero ,  Robert McKay

IPC分类号： C07H2104

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y207/11024 ,  Y02P20/582 ,  C12N2310/3525

摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for the treatment and diagnosis of diseases or conditions associated with aberrant expression of one or more p38 MAPKs are also provided.

摘要翻译： 提供了用于治疗和诊断适于通过调节编码p38丝裂原活化蛋白激酶（p38MAPK）的基因的表达进行治疗的疾病或病症的组合物和方法。 还提供了用于治疗和诊断与一种或多种p38 MAPK的异常表达相关的疾病或病症的方法。

公开(公告)号：US06238921B1

公开(公告)日：2001-05-29

申请号：US09048810

申请日：1998-03-26

申请人： Loren J. Miraglia ,  Pamela Nero ,  Mark J. Graham ,  Brett P. Monia

发明人： Loren J. Miraglia ,  Pamela Nero ,  Mark J. Graham ,  Brett P. Monia

IPC分类号： C12N1585

CPC分类号： C12N15/113 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/335 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525 ,  C12N2310/3521

摘要： Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.

摘要翻译： 提供化合物，组合物和方法用于抑制人mdm2的表达。 组合物包含靶向编码mdm2的核酸的反义寡核苷酸。 提供了使用这些寡核苷酸抑制mdm2表达和治疗诸如与mdm2过度表达相关的癌症的疾病的方法。