发明授权
US06184365B2 Anthracycline derivatives having 4-amino-2,4,6-trideoxy-2 fluoro-&agr;-L-talopyranosyl group
失效
具有4-氨基-2,4,6-三脱氧-2氟-α-L-吡喃葡萄糖基的蒽环类衍生物
- 专利标题： Anthracycline derivatives having 4-amino-2,4,6-trideoxy-2 fluoro-&agr;-L-talopyranosyl group
- 专利标题（中）： 具有4-氨基-2,4,6-三脱氧-2氟-α-L-吡喃葡萄糖基的蒽环类衍生物
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申请号： US08991436申请日： 1997-12-16
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公开(公告)号： US06184365B2公开(公告)日： 2001-02-06
- 发明人: Tomio Takeuchi , Sumio Umezawa , Tsutomu Tsuchiya , Yasushi Takagi
- 申请人： Tomio Takeuchi , Sumio Umezawa , Tsutomu Tsuchiya , Yasushi Takagi
- 优先权： JP8-335913 19960216
- 主分类号： C07H100
- IPC分类号： C07H100
摘要：
7-O-(4-Amino-2,4,6-trideoxy-2-fluoro-&agr;-L-talopyranosyl)-daunomycinone or -adriamycinone is now synthesized as a novel daunomycinone or adriamycinone derivative having the general formula wherein R is a hydrogen atom or hydroxyl group. These novel compounds according to this invention exhibit excellent antitumor activities and have a high solubility in water, and hence they are useful as an antitumor agent.
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