发明授权
US06225458B1 Process for the production of DNA comprising the genome of the hepatitis B virus and vector including it
失效
用于生产包含乙型肝炎病毒基因组的DNA和包含它的载体的方法
- 专利标题： Process for the production of DNA comprising the genome of the hepatitis B virus and vector including it
- 专利标题（中）： 用于生产包含乙型肝炎病毒基因组的DNA和包含它的载体的方法
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申请号： US08347162申请日： 1994-11-23
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公开(公告)号： US06225458B1公开(公告)日： 2001-05-01
- 发明人: Pierre Tiollais , Alex Fritsch , Christine Pourcel , Patrick Charnay
- 申请人： Pierre Tiollais , Alex Fritsch , Christine Pourcel , Patrick Charnay
- 优先权： FR7835588 19781218
- 主分类号： A61K3929
- IPC分类号： A61K3929
摘要：
The invention relates to a process for producing DNA corresponding to that of the DNA of the virus of B hepatitis. It comprises cloning in bacteria the latter DNA, previously repaired by means of the corresponding precursor nucleotides in the presence of a polymerase. The invention also relates to vectors containing said cloned DNA in their genomes. The cloned DNA is useful as a probe for detecting the presence of the virus of B hepatitis in biological samples, particularly blood or plasma. Its expression in bacteria provides a hybrid protein containing a protein fragment having vaccinating properties against hepatitis B.
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