发明授权
- 专利标题： Macrocyclic compounds as metalloprotease inhibitors
- 专利标题（中）： 大环化合物作为金属蛋白酶抑制剂
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申请号： US08856223申请日： 1997-05-14
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公开(公告)号： US06281352B1公开(公告)日： 2001-08-28
- 发明人: Chu-Bio Xue , Carl P. Decicco , Robert J. Cherney , Elizabeth Arner , William F. DeGrado , Jingwu Duan , Xiaohua He , Irina Cipora Jacobson , Ronald L. Magolda , David Nelson
- 申请人： Chu-Bio Xue , Carl P. Decicco , Robert J. Cherney , Elizabeth Arner , William F. DeGrado , Jingwu Duan , Xiaohua He , Irina Cipora Jacobson , Ronald L. Magolda , David Nelson
- 主分类号： A61K3133
- IPC分类号： A61K3133
摘要：
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.
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