Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof

发明授权

US06281381B1 Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof 失效

标题翻译：阿仑膦酸钠的水合物形式，其制备方法及其药物组合物

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专利标题： Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
专利标题（中）： 阿仑膦酸钠的水合物形式，其制备方法及其药物组合物
申请号： US09384145

申请日： 1999-08-27
公开(公告)号： US06281381B1

公开(公告)日： 2001-08-28
发明人: Nina Finkelstein , Ramy Lidor-Hadas , Judith Aronhime
申请人： Nina Finkelstein , Ramy Lidor-Hadas , Judith Aronhime
主分类号： C07F938
IPC分类号： C07F938

Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof

摘要：

New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.

摘要（中）：

公开了水含量为约1至约12％的阿仑膦酸钠的新水合物形式及其制备方法。还公开了阿仑膦酸钠B，D，E，F，G和H的新结晶形式及其制备方法。这些新形式的阿仑膦酸钠适于掺入用于对抗骨疾病中的骨吸收的药物组合物中。

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