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公开(公告)号：US07598420B1
公开(公告)日：2009-10-06
申请号：US12283105
申请日：2008-09-08
申请人： Jeffrey Sterling , David Lerner , Harel Rosen , Leonid Bronov , Dalia Medini-Green , Berta Iosefzon , Tirtsah Berger-Peskin , Ramy Lidor-Hadas , Eliezer Bahar
发明人： Jeffrey Sterling , David Lerner , Harel Rosen , Leonid Bronov , Dalia Medini-Green , Berta Iosefzon , Tirtsah Berger-Peskin , Ramy Lidor-Hadas , Eliezer Bahar
IPC分类号： C07C211/42 , C07C209/84
CPC分类号： A61K31/135 , A61K9/2018 , A61K9/2059 , C07C211/42
摘要： The subject invention provides a pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in total of a compound having the structure: and any salts of the compound.
摘要翻译： 本发明提供包含N-炔丙基-1（R） - 氨基茚满甲磺酸酯的药物组合物; 药学上可接受的载体; 和具有以下结构的化合物的总和大于0.7ppm但小于30ppm：和化合物的任何盐。
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公开(公告)号：US07572834B1
公开(公告)日：2009-08-11
申请号：US11634916
申请日：2006-12-05
申请人： Jeffrey Sterling , David Lerner , Harel Rosen , Leonid Bronov , Dalia Medini-Green , Berta Iosefzon , Tirtsah Berger-Peskin , Ramy Lidor-Hadas , Eliezer Bahar
发明人： Jeffrey Sterling , David Lerner , Harel Rosen , Leonid Bronov , Dalia Medini-Green , Berta Iosefzon , Tirtsah Berger-Peskin , Ramy Lidor-Hadas , Eliezer Bahar
IPC分类号： A61K31/135 , C07C211/42
CPC分类号： A61K31/135 , A61K9/2018 , A61K9/2059 , C07C211/42
摘要： The subject invention provides a pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in total of a compound having the structure: and any salts of the compound.
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3.发明授权Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms 失效阿伐他汀半钙的晶体形式及其制备方法以及制备其他形式的新方法公开(公告)号：US07488750B2
公开(公告)日：2009-02-10
申请号：US11257828
申请日：2005-10-24
IPC分类号： C07D207/34 , A61K31/40
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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公开(公告)号：US07468444B2
公开(公告)日：2008-12-23
申请号：US11257979
申请日：2005-10-24
IPC分类号： C07D207/34 , A61K31/40
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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5.发明申请Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel process for preparing other forms 审中-公开阿伐他汀半钙的新型晶体形式及其制备方法以及制备其他形式的新方法公开(公告)号：US20080214650A1
公开(公告)日：2008-09-04
申请号：US11977387
申请日：2007-10-23
IPC分类号： A61K31/401 , C07D207/34
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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公开(公告)号：US06605636B2
公开(公告)日：2003-08-12
申请号：US09992746
申请日：2001-11-05
IPC分类号： A61K3140
CPC分类号： C07D405/06 , A61K31/40 , C07D207/34
摘要： The present invention provides a novel form of atorvastatin hemi-calcium designated Form VII and novel processes for its preparation whereby another crystalline form of atorvastatin hemi-calcium is suspended in ethanol, preferably absolute ethanol, and is converted to the new form, which is then isolated. The present invention further provides a method of reducing the plasma low density lipoprotein level in patients suffering from or susceptible to hypercholesterolemia and compositions and dosage forms for practicing the invention.
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公开(公告)号：US07491847B2
公开(公告)日：2009-02-17
申请号：US11600561
申请日：2006-11-15
申请人： Anton Frenkel , Ramy Lidor-Hadas , Eduard Gurevich , Gsan Attili
发明人： Anton Frenkel , Ramy Lidor-Hadas , Eduard Gurevich , Gsan Attili
IPC分类号： C07C211/42 , C07C271/44 , A61K31/21 , A61K31/135
CPC分类号： C07C209/86 , C07C209/84 , C07C2602/08 , C07C211/42
摘要： A process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan, a process for isolating from a reaction mixture a crystalline diastereomeric salt of a mono-propargylated aminoindan, and a process for isolating from a reaction mixture a salt of enantiomerically pure N-propargyl-1-aminoindan or a salt of enantiomerically pure 6-(N-methyl, N-ethyl-carbamoyloxy)-N′-propargyl-1-aminoindan. The corresponding products are also disclosed.
摘要翻译： 从反应混合物中分离单炔丙基化氨基茚满盐的方法，从反应混合物中分离出单炔丙基化氨基茚满的结晶非对映体盐的方法和从反应混合物中分离出对映异构体纯的盐的方法 N-炔丙基-1-氨基茚满或对映体纯的6-（N-甲基，N-乙基 - 氨基甲酰氧基）-N'-炔丙基-1-氨基茚满的盐。 相应的产品也被披露。
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公开(公告)号：US20060100446A1
公开(公告)日：2006-05-11
申请号：US11257828
申请日：2005-10-24
申请人： Judith Aronhime , Ramy Lidor-Hadas , Valerie Niddam-Hildesheim , Revital Lifshitz-Liron , Shlomit Wizel
发明人： Judith Aronhime , Ramy Lidor-Hadas , Valerie Niddam-Hildesheim , Revital Lifshitz-Liron , Shlomit Wizel
IPC分类号： C07D207/24
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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公开(公告)号：US20060100267A1
公开(公告)日：2006-05-11
申请号：US11257886
申请日：2005-10-24
申请人： Judith Aronhime , Ramy Lidor-Hadas , Valerie Niddam-Hildesheim , Revital Lifshitz-Liron , Shlomit Wizel
发明人： Judith Aronhime , Ramy Lidor-Hadas , Valerie Niddam-Hildesheim , Revital Lifshitz-Liron , Shlomit Wizel
IPC分类号： A61K31/401 , C07D207/24
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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10.发明申请Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms 失效阿伐他汀半钙的新型晶体形式及其制备方法以及制备其它形式的新方法公开(公告)号：US20050090542A1
公开(公告)日：2005-04-28
申请号：US10994142
申请日：2004-11-19
IPC分类号： A61K9/28 , A61K9/50 , A61K31/40 , A61K31/401 , A61P3/06 , A61P9/00 , B01D9/02 , C07D207/34 , C07D405/06
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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