发明授权
- 专利标题: Method for the production of 1-substituted 5-hydroxypyrazoles
- 专利标题(中): 1-取代的5-羟基吡唑的制备方法
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申请号: US09830948申请日: 2001-05-03
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公开(公告)号: US06329530B1公开(公告)日: 2001-12-11
- 发明人: Volker Maywald , Adrian Steinmetz , Michael Rack , Norbert Götz , Roland Götz , Jochem Henkelmann , Heike Becker , Juan Jose Aiscar Bayeto
- 申请人: Volker Maywald , Adrian Steinmetz , Michael Rack , Norbert Götz , Roland Götz , Jochem Henkelmann , Heike Becker , Juan Jose Aiscar Bayeto
- 优先权: DE19853501 19981119
- 主分类号: C07D23120
- IPC分类号: C07D23120
摘要:
The invention relates to a method for the production of 1-substituted 5-hydroxypyrazoles of formula (I) wherein R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C6-cycloalkyl or C1-C4-alkoxy, whereby these groups can be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or a cyclic ring system with 3-14 ring atoms, by reacting a) an alkylvinylether of general formula (III) wherein R2 is C1-C6-alkyl or C3-C6-cycloalkyl, with phosgene (IVa), “diphosgene” (IVb) or “triphosgene” (IVc) to form acid chlorides of formula (V), b) transforming said acid chlorides by eliminating hydrogen chloride into the corresponding 3-alkoxyacrylic acid chloride of formula (VI) and c) reacting said acid chloride with hydrazines of formula (VII) wherein R1 has the above cited meaning, to form 5-hydroxypyrazoles of formula (I).
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