发明授权
- 专利标题: Non-planar microstructures for manipulation of fluid samples
- 专利标题(中): 用于操作流体样品的非平面微结构
-
申请号: US08910434申请日: 1997-08-13
-
公开(公告)号: US06368871B1公开(公告)日: 2002-04-09
- 发明人: Lee Allan Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi
- 申请人: Lee Allan Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi
- 主分类号: G01N110
- IPC分类号: G01N110
摘要:
This invention comprises an apparatus and method for the manipulation of materials, including particles, cells, macromolecules, such as proteins, nucleic acids and other moieties, in fluid samples. The apparatus comprises an enclosed chamber on a chip having an internal microstructure with surface area substantially greater than the facial surface area of the internal structure. Generally the internal microstructure comprises a continuous network of channels, each of which has a depth substantially greater than its width. The network may comprise a single channel, a single channel with multiple branches, multiple channels, multiple channels with multiple branches, and any combination thereof. The internal structure may present an inert, non-reactive surface, or be coated with a reactive ligand, or be electrically conductive and optionally be coated with an electrical insulator. Discrete portions of the internal structure may differ in structural and surface properties. Multiple chips may be linked together to create a multiplexed array of chambers, optionally linked to other analytical devices.