发明授权
US06372735B1 Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic
有权
三环三氮苯并氮杂衍生物，其制备方法和抗过敏剂
- 专利标题： Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic
- 专利标题（中）： 三环三氮苯并氮杂衍生物，其制备方法和抗过敏剂
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申请号： US09509494申请日： 2000-03-29
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公开(公告)号： US06372735B1公开(公告)日： 2002-04-16
- 发明人: Yasuo Ohtsuka , Toshio Nishizuka , Sohjiro Shiokawa , Seiji Tsutsumi , Mami Kawaguchi , Hideo Kitagawa , Hiromi Takata , Takashi Shishikura , Toyoaki Ishikura , Kenichi Fushihara , Yumiko Okada , Sachiko Miyamoto , Maki Shiobara
- 申请人： Yasuo Ohtsuka , Toshio Nishizuka , Sohjiro Shiokawa , Seiji Tsutsumi , Mami Kawaguchi , Hideo Kitagawa , Hiromi Takata , Takashi Shishikura , Toyoaki Ishikura , Kenichi Fushihara , Yumiko Okada , Sachiko Miyamoto , Maki Shiobara
- 优先权： JP9-264611 19970929; JP10-052063 19980304
- 主分类号： A61K3155
- IPC分类号： A61K3155
摘要：
Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R1 represents hydrogen, OH, alkyl or phenyl alkyl, R2, R3, R4, and R5 represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy:
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