发明授权
- 专利标题： Human DNA mismatch repair proteins
- 专利标题（中）： 人类DNA错配修复蛋白
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申请号： US08294312申请日： 1994-08-23
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公开(公告)号： US06380369B1公开(公告)日： 2002-04-30
- 发明人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
- 申请人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
- 主分类号： C07H2102
- IPC分类号： C07H2102
摘要：
The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins which may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.