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    Lung cancer markers, and uses thereof
    2.
    发明授权
    Lung cancer markers, and uses thereof 有权
    肺癌标志物及其用途

    公开(公告)号：US08808997B2

    公开(公告)日：2014-08-19

    申请号：US13005031

    申请日：2011-01-12

    Applicant: Charles Birse ,  Marcia Lewis ,  Steve Ruben ,  Mehdi Mesri

    Inventor： Charles Birse ,  Marcia Lewis ,  Steve Ruben ,  Mehdi Mesri

    IPC: G01N33/53

    CPC classification number: G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/8114 ,  G01N2333/96486 ,  G01N2800/56

    Abstract: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

    Abstract translation: 提供了使用肺癌标志物（LCM）评估（例如诊断），治疗和预防疾病，特别是癌症和特定肺癌的方法和组合物。 为这些和其他用途提供了单个LCM和包含多个LCM的面板。 还提供了用于确定或预测治疗的有效性或使用LCM选择治疗的方法和组合物。 还提供了使用LCM调节细胞功能的方法和组合物。 还提供了调节LCM的组合物（例如拮抗剂或激动剂），例如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义剂），以及其药物组合物。 还提供了筛选调节LCM的试剂的方法以及通过这些筛选方法鉴定的试剂。

    Breast disease targets and uses thereof
    7.
    发明授权
    Breast disease targets and uses thereof 有权
    乳腺疾病的目标及其用途

    公开(公告)号：US07842467B1

    公开(公告)日：2010-11-30

    申请号：US12156431

    申请日：2008-05-29

    Applicant: Jenny Heidbrink ,  Steve Ruben ,  Charles E. Birse ,  Tao He

    Inventor： Jenny Heidbrink ,  Steve Ruben ,  Charles E. Birse ,  Tao He

    IPC: G01N33/53

    CPC classification number: G01N33/57415

    Abstract: The present invention provides a method for diagnosing and detecting diseases associated with breast. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in breast diseases (BCAT) and antibodies binds to BCAT. The present invention provides that BCAT is used as targets for screening agents that modulates the BCAT activities. Further the present invention provides methods for treating diseases associated with breast.

    Abstract translation: 本发明提供了诊断和检测与乳腺相关疾病的方法。 本发明提供在乳腺疾病（BCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合BCAT。 本发明提供了将BCAT用作调节BCAT活性的筛选试剂的靶标。 此外，本发明提供了治疗与乳腺相关疾病的方法。

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