公开(公告)号：US06806358B1

公开(公告)日：2004-10-19

申请号：US09215569

申请日：1998-12-16

Applicant: Ethan Bier ,  Kweon Yu

Inventor： Ethan Bier ,  Kweon Yu

IPC: C07H2102

CPC classification number: C07K14/43581 ,  C07H21/02 ,  Y10S530/858

Abstract: A potent peptide inhibitor (SuperSog) of TGF-&bgr; family growth factor signalling, peptide variants thereof and nucleotide coding sequences therefor are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.

Abstract translation: 本发明提供TGF-β家族生长因子信号传导的有效肽抑制剂（SuperSog），其肽变体及其核苷酸编码序列。 超级谷氨肽包含果糖的富含CR-1半胱氨酸的重复序列的果蝇短胃蛋白（Sog）基因的片段。 还提供了在治疗和诊断应用中使用Super-Sog的方法和组合物。

公开(公告)号：US06797818B2

公开(公告)日：2004-09-28

申请号：US10047874

申请日：2002-01-14

Applicant: Hendrick Jan Houthoff ,  Jan Reedijk ,  Tinka Jelsma ,  Robert Jochem Heetebrij ,  Herman Hendricus Volkers

Inventor： Hendrick Jan Houthoff ,  Jan Reedijk ,  Tinka Jelsma ,  Robert Jochem Heetebrij ,  Herman Hendricus Volkers

IPC: C07H2102

CPC classification number: C07H23/00 ,  C07H21/00 ,  Y10S436/80 ,  Y10T436/143333

Abstract: The present invention provides a labeled nucleotide having formula: where X is an aliphatic diamine, and the labeling moiety comprises a label and a spacer, where the spacer is coupled at one end to a platinum atom and at the other end to the label, which spacer comprises a chain having at least four atoms. The invention further provides a method for labeling a nucleotide, kits for labeling a nucleotide, and kits containing labeled nucleotides.

Abstract translation: 本发明提供了一种标记的核苷酸，其具有式：其中X是脂族二胺，标记部分包括标记和间隔基，其中间隔物一端与铂原子结合，另一端与标记偶联， 间隔基包含具有至少四个原子的链。 本发明还提供了用于标记核苷酸的方法，用于标记核苷酸的试剂盒和含有标记核苷酸的试剂盒。

公开(公告)号：US06787641B1

公开(公告)日：2004-09-07

申请号：US09043944

申请日：2000-10-06

Applicant: Iva Greenwald ,  Diane Levitan

Inventor： Iva Greenwald ,  Diane Levitan

IPC: C07H2102

CPC classification number: C07K14/43545 ,  A01K2217/05 ,  A61K38/00

Abstract: This invention provides an isolated nucleic acid molecule encoding a SEL-12. This invention further provides an isolated nucleic acid molecule which encodes a mutated SEL-12. This invention also provides an isolated nucleic acid molecule which encodes a mutated SEL-12, wherein the mutated SEL-12 contains at least one of the following: position 115 is a leucine, position 132 is an arginine, position 215 is a glutamic acid, position 229 is a valine, position 254 is a valine, position 255 is a valine, position 371 is a valine, position 387 is a tyrosine, position 104 is an isoleucine or position 204 is a valine, This invention further provides different uses of these nucleic acid molecules. This invention also provides different sel-12 mutants and transgenic animals which carry wild-type or mutated sel-12.

Abstract translation: 本发明提供了编码SEL-12的分离的核酸分子。 本发明还提供了编码突变的SEL-12的分离的核酸分子。 本发明还提供了编码突变的SEL-12的分离的核酸分子，其中突变的SEL-12含有以下至少一种：位置115是亮氨酸，位置132是精氨酸，位置215是谷氨酸， 位置229是缬氨酸，位置254是缬氨酸，位置255是缬氨酸，位置371是缬氨酸，位置387是酪氨酸，位置104是异亮氨酸或位置204是缬氨酸。本发明进一步提供了这些 核酸分子。 本发明还提供携带野生型或突变型sel-12的不同的sel-12突变体和转基因动物。

公开(公告)号：US06759529B1

公开(公告)日：2004-07-06

申请号：US09641540

申请日：2000-08-18

Applicant: Santosh Misra ,  Malinee Chattai

Inventor： Santosh Misra ,  Malinee Chattai

IPC: C07H2102

CPC classification number: C12N15/823 ,  C07K14/825

Abstract: The invention provides promoters from Douglas-fir genes encoding metallothionein-like proteins. Also provided are deletions and variants of such promoters. The promoters are useful for, among other things, directing developmental-specific expression of transgenes.

Abstract translation: 本发明提供了编码金属硫蛋白样蛋白的道格拉斯冷杉基因的启动子。 还提供了这种启动子的缺失和变体。 除了别的以外，启动子可用于指导转基因的发育特异性表达。

公开(公告)号：US06759525B2

公开(公告)日：2004-07-06

申请号：US09935916

申请日：2001-08-23

Applicant: Constantine Stratakis ,  Lawrence Kirschner

Inventor： Constantine Stratakis ,  Lawrence Kirschner

IPC: C07H2102

CPC classification number: C12N9/1205

Abstract: The present invention provides compositions and methods useful in the diagnosis and prognosis of Carney complex (CNC), as well as methods and compositions for the identification of compounds useful in the treatment and/or prevention of CNC. In addition, the present invention provides compositions and methods useful in the diagnosis and treatment of conditions associated with skin pigmentation defects, including but not limited to freckling, as well as endocrine tumors including, but not limited to adrenal and pituitary tumors. In addition, the present invention provides methods and compositions for the diagnosis and treatment of various types of cancers associated with abnormal activity of protein kinase A. In particular, the present invention provides genetic and other sequence information, as well as assay systems that will find use in these and related areas.

Abstract translation: 本发明提供了可用于卡尼络合物（CNC）的诊断和预后的组合物和方法，以及用于鉴定可用于治疗和/或预防CNC的化合物的方法和组合物。 此外，本发明提供了用于诊断和治疗与皮肤色素沉着缺陷相关的病症（包括但不限于雀斑以及内分泌肿瘤）的组合物和方法，包括但不限于肾上腺和垂体瘤。 此外，本发明提供了用于诊断和治疗与蛋白激酶A的异常活性相关的各种类型的癌症的方法和组合物。特别地，本发明提供遗传和其他序列信息以及将发现的测定系统 在这些和相关领域使用。

公开(公告)号：US06753421B2

公开(公告)日：2004-06-22

申请号：US09544934

申请日：2000-04-07

Applicant: Henrik Stender ,  Kaare Lund ,  Tina Anderson Mollerup

Inventor： Henrik Stender ,  Kaare Lund ,  Tina Anderson Mollerup

IPC: C07H2102

CPC classification number: C07K14/003 ,  C12Q1/689

Abstract: Novel hybridisation assay probes and mixtures of such probes for detecting a target sequence of one or mycobacteria optionally present in a sample. The probes may suitable be directed to target sequences of mycobacterial rDNA, precursor rRNA or rRNA, said probes being capable of forming detectable hybrids. The probes are in particular directed to mycobacterial rDNA, to precursor rRNA, or to 23S, 16S or 5S rRNA. The probes are useful for detecting the organisms in test samples such as sputum, laryngeal swabs, gastric lavage, bronchial washings, biopsies, aspirates, expectorates, body fluids (spinal, pleural, pericardial synovial, blood, pus, bone marrow), urine, tissue sections as well as food samples, soil, air and water samples, and cultures thereof.

Abstract translation: 新型杂交测定探针和这种探针的混合物，用于检测任选存在于样品中的一种或分枝杆菌的靶序列。 探针可以适用于分枝杆菌rDNA，前体rRNA或rRNA的靶序列，所述探针能够形成可检测的杂交体。 探针特别针对分枝杆菌rDNA，前体rRNA或23S，16S或5S rRNA。 探针可用于检测试验样品中的生物，如痰液，喉拭子，胃灌洗液，支气管洗液，活组织检查，抽吸物，痰液，体液（脊髓，胸膜，心包滑膜，血液，脓液，骨髓），尿液， 组织切片以及食物样品，土壤，空气和水样品及其培养物。

公开(公告)号：US06747136B2

公开(公告)日：2004-06-08

申请号：US08844215

申请日：1997-04-17

Applicant: Mats Axel Atterdag Persson ,  Tobias Erik Allander

Inventor： Mats Axel Atterdag Persson ,  Tobias Erik Allander

IPC: C07H2102

CPC classification number: C07K16/109 ,  A61K38/00 ,  A61K39/42 ,  C07K2319/00 ,  A61K2300/00

Abstract: The present invention relates to compositions derived from immunoglobulin molecules specific for the hepatitis C virus (HCV). More particularly, the invention is related to molecules which are capable of specifically binding with HCV E2 antigen. The molecules are useful in specific binding assays, affinity purification schemes and pharmaceutical compositions for the prevention and treatment of HCV infection in mammalian subjects. The invention thus relates to novel human monoclonal antibodies specific for HCV E2 antigen, fragments of such monoclonal antibodies, polypeptides having structure and function substantially homologous to antigen-binding sites obtained from such monoclonal antibodies, nucleic acid molecules encoding those polypeptides, and expression vectors comprising the nucleic acid molecules.

Abstract translation: 本发明涉及由丙型肝炎病毒（HCV）特异的免疫球蛋白分子衍生的组合物。 更具体地，本发明涉及能够与HCV E2抗原特异性结合的分子。 该分子可用于特异性结合测定，亲和纯化方案和用于预防和治疗哺乳动物受试者中HCV感染的药物组合物。 因此，本发明涉及对HCV E2抗原特异性的新型人单克隆抗体，这种单克隆抗体的片段，具有与从这些单克隆抗体获得的抗原结合位点，编码那些多肽的结构和功能基本同源的多肽，以及包含 核酸分子。

公开(公告)号：US06703197B1

公开(公告)日：2004-03-09

申请号：US08980326

申请日：1997-11-26

Applicant: Roy A. Gravel ,  Rima Rozen ,  Daniel LeClerc ,  Philippe Goyette ,  Eric Campeau

Inventor： Roy A. Gravel ,  Rima Rozen ,  Daniel LeClerc ,  Philippe Goyette ,  Eric Campeau

IPC: C07H2102

CPC classification number: C12Q1/6883 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156

Abstract: The invention features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects or cardiovascular disease. The invention also features therapeutic methods for reducing the risk of neural tube defects, colon cancers and related cancers. Also provided are the sequences of the human methionine synthase gene and protein and compounds and kits for performing the methods of the invention.

Abstract translation: 本发明的特征在于一种用于检测高同型半胱氨酸血症的可能性增加的方法，反过来，神经管缺陷或心血管疾病的可能性增加或降低。 本发明还具有降低神经管缺陷，结肠癌和相关癌症风险的治疗方法。 还提供了人甲硫氨酸合酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。

公开(公告)号：US06699980B1

公开(公告)日：2004-03-02

申请号：US09514768

申请日：2000-02-28

Applicant: Anthony T. Yeung

Inventor： Anthony T. Yeung

IPC: C07H2102

CPC classification number: C12N9/22 ,  C12Q1/683 ,  C12Q2600/156 ,  C12Q2537/113

Abstract: Nucleic acid molecules encoding a mismatch endonuclease and its method of use for the detection of mutations in targeted polynucleotide sequences are provided, which facilitate the localization and identification of mutations, mismatches and genetic polymorphisms.

Abstract translation: 提供编码错配核酸内切酶的核酸分子及其用于检测靶向多核苷酸序列突变的方法，其有助于突变，错配和遗传多态性的定位和鉴定。

公开(公告)号：US06683171B1

公开(公告)日：2004-01-27

申请号：US09697341

申请日：2000-10-25

Applicant: Mary E. Brunkow ,  Eric W. Jeffery ,  Kathryn A. Hjerrild ,  Fred Ramsdell

Inventor： Mary E. Brunkow ,  Eric W. Jeffery ,  Kathryn A. Hjerrild ,  Fred Ramsdell

IPC: C07H2102

CPC classification number: G01N33/54346 ,  A61K31/70 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  G01N33/587

Abstract: Isolated nucleic acid molecules are provided which encode Fkhsf, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system.