发明授权
US06441185B2 Method for producing thiazolidinediones, and new thiazolidinediones
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噻唑烷二酮的制备方法,新的噻唑烷二酮类
- 专利标题: Method for producing thiazolidinediones, and new thiazolidinediones
- 专利标题(中): 噻唑烷二酮的制备方法,新的噻唑烷二酮类
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申请号: US09783494申请日: 2001-02-14
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公开(公告)号: US06441185B2公开(公告)日: 2002-08-27
- 发明人: Hans-Frieder Kühnle , Ernst-Christian Witte , Hans-Peter Wolff
- 申请人: Hans-Frieder Kühnle , Ernst-Christian Witte , Hans-Peter Wolff
- 优先权: DE19711616 19970320
- 主分类号: C07D41714
- IPC分类号: C07D41714
摘要:
Improved process of compounds of formula III in which A denotes CH═CH or S W denotes O X denotes S, O or NR2 in which the residue R2 is hydrogen or C1-C6 alkyl, Y denotes CH or N R denotes naphthyl, thienyl or phenyl which is optionally monosubstituted or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R1 denotes hydrogen or C1-C6 alkyl and n denotes 1-3 by reducing a compound of the general formula IV, in which A, W, X, Y, R, R1 and n have the meanings stated above with activated aluminum in a protic solvent, as well as new compounds of formula III and pharmaceutical preparations containing these compounds.
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