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公开(公告)号：US06441185B2
公开(公告)日：2002-08-27
申请号：US09783494
申请日：2001-02-14
IPC分类号： C07D41714
CPC分类号： C07D417/12 , C07D417/14
摘要： Improved process of compounds of formula III in which A denotes CH═CH or S W denotes O X denotes S, O or NR2 in which the residue R2 is hydrogen or C1-C6 alkyl, Y denotes CH or N R denotes naphthyl, thienyl or phenyl which is optionally monosubstituted or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R1 denotes hydrogen or C1-C6 alkyl and n denotes 1-3 by reducing a compound of the general formula IV, in which A, W, X, Y, R, R1 and n have the meanings stated above with activated aluminum in a protic solvent, as well as new compounds of formula III and pharmaceutical preparations containing these compounds.
摘要翻译： 式III化合物的改进方法，其中A表示CH = CH或SW表示OX表示其中残基R2为氢或C1-C6烷基，Y表示CH或NR的S，O或NR2表示萘基，噻吩基或任选单取代的苯基 或被C 1 -C 3烷基，CF 3，C 1 -C 3烷氧基，F，Cl或溴二取代，R 1表示氢或C 1 -C 6烷基，并且n表示1-3，通过还原通式IV的化合物，其中A，W，X ，Y，R，R 1和n在质子溶剂中具有上述活化的铝，以及新的式III化合物和含有这些化合物的药物制剂。
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公开(公告)号：US06258832B1
公开(公告)日：2001-07-10
申请号：US09381247
申请日：1999-09-14
IPC分类号： A61K31427
CPC分类号： C07D417/12 , C07D417/14
摘要： Improved process of compound of formula III in which A denotes CH═CH or S W denotes O X denotes S, O or NR2 in which the residue R2 is hydrogen or C1-C6 alkyl, Y denotes CH or N R denotes naphthyl, thienyl or phenyl which is optionally monosubstituted or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R1 denotes hydrogen or C1-C6 alkyl and n denotes 1-3 by reducing a compound of the general formula IV, in which A, W, X, Y, R, R1 and n have the meanings stated above with activated aluminium in a protic solvent, as well as new compounds of formula III and pharmaceutical preparations containing these compounds.
摘要翻译： 式III化合物的改进方法，其中A表示CH = CH或SW表示OX表示其中残基R 2为氢或C 1 -C 6烷基，Y表示CH或NR的S，O或NR 2表示萘基，噻吩基或任选被单取代的苯基 或被C 1 -C 3烷基，CF 3，C 1 -C 3烷氧基，F，Cl或溴二取代，R 1表示氢或C 1 -C 6烷基，并且n表示1-3，通过还原通式IV的化合物，其中A，W，X ，Y，R，R 1和n在质子溶剂中具有上述活化的铝，以及新的式III化合物和含有这些化合物的药物制剂。
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