发明授权
- 专利标题: Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
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申请号: US10108817申请日: 2002-03-27
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公开(公告)号: US06492422B2公开(公告)日: 2002-12-10
- 发明人: Patrick Michael O'Brien , Joseph Armand Picard , Drago Robert Sliskovic
- 申请人: Patrick Michael O'Brien , Joseph Armand Picard , Drago Robert Sliskovic
- 主分类号: C07C31121
- IPC分类号: C07C31121
摘要:
Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.