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    Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors
    1.
    发明授权
    Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors 失效
    羟肟酸化合物可用作基质金属蛋白酶抑制剂

    公开(公告)号：US06677355B1

    公开(公告)日：2004-01-13

    申请号：US10049544

    申请日：2002-02-13

    申请人： Christopher Alan Conrad ,  Patrick Michael O'Brien ,  Daniel Fred Ortwine ,  Joseph Armand Picard ,  Drago Robert Sliskovic

    发明人： Christopher Alan Conrad ,  Patrick Michael O'Brien ,  Daniel Fred Ortwine ,  Joseph Armand Picard ,  Drago Robert Sliskovic

    IPC分类号： C07D30791

    CPC分类号： C07D307/91 ,  C07C311/19 ,  C07C311/20 ,  C07C2601/08 ,  C07C2601/14 ,  C07D307/93 ,  C07D407/12

    摘要： Compounds of the formula; are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such compounds, pharmaceutical compositions including the same, and methods of treating diseases in which matrix metalloproteinases are involved including multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurysm, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, osteoporosis, rheumatoid or osteoarthritis, renal disease, left ventricular dilation, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.

    摘要翻译： 式的化合物可用于抑制动物中的基质金属蛋白酶，因此预防和治疗由结缔组织破裂引起的疾病。 还公开了制备这些化合物的方法，包括其的药物组合物，以及治疗其中涉及基质金属蛋白酶的疾病的方法，包括多发性硬化，动脉粥样硬化斑块破裂，再狭窄，主动脉瘤，心力衰竭，牙周病，角膜溃疡， 烧伤，褥疮性溃疡，慢性溃疡或创伤，癌症转移，肿瘤血管发生，骨质疏松症，类风湿性关节炎，骨关节炎，肾脏疾病，左心室扩张或依赖于白细胞组织侵袭的其他自身免疫性或炎性疾病。

    Method of inhibiting matrix metalloproteinases
    5.
    发明授权
    Method of inhibiting matrix metalloproteinases 失效
    抑制基质金属蛋白酶的方法

    公开(公告)号：US06620835B2

    公开(公告)日：2003-09-16

    申请号：US10162518

    申请日：2002-06-04

    申请人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    发明人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    IPC分类号： A61K31381

    CPC分类号： C07D307/91 ,  A61K31/343 ,  A61K31/381 ,  C07C311/19 ,  C07C2603/18 ,  C07D333/76

    摘要： The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.

    摘要翻译： 本发明涉及使用具有式IIIO的二苯并呋喃磺酰胺衍生物的化合物抑制基质金属蛋白酶的方法，本发明涉及治疗涉及基质金属蛋白酶的疾病的方法，例如多发性硬化，动脉粥样硬化斑块破裂，再狭窄 ，主动脉瘤，心力衰竭，牙周病，角膜溃疡，烧伤，褥疮性溃疡，慢性溃疡或创伤，癌症转移，肿瘤血管生成，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎性疾病。

    Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
    7.
    发明授权
    Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases 失效
    三环异构体及其衍生物作为基质金属蛋白酶抑制剂

    公开(公告)号：US06350885B1

    公开(公告)日：2002-02-26

    申请号：US09719026

    申请日：2001-02-20

    申请人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic

    发明人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic

    IPC分类号： C07D30791

    CPC分类号： C07D209/80 ,  C07C59/86 ,  C07D209/86 ,  C07D209/94 ,  C07D233/78 ,  C07D307/91 ,  C07D333/76

    摘要： Tricyclic heteroaromatic compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, renal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    摘要翻译： 描述了三环杂芳族化合物和衍生物以及其制备方法及其药物组合物，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A，胶原酶-3和溶基质蛋白酶-1以及治疗多发性硬化，动脉粥样硬化 斑块破裂，主动脉瘤，心力衰竭，左心室扩张，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮溃疡，伤口愈合，癌症，炎症，疼痛，关节炎，骨质疏松症，肾脏疾病或其他自身免疫性或炎症性疾病 依赖于白细胞或其他活化的迁移细胞的组织侵袭，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病，肌无力 重症肌无力和Duchenne肌营养不良症。

    Matrix metalloproteinase inhibitors and their therapeutic uses
    9.
    发明授权
    Matrix metalloproteinase inhibitors and their therapeutic uses 失效
    基质金属蛋白酶抑制剂及其治疗用途

    公开(公告)号：US06624177B1

    公开(公告)日：2003-09-23

    申请号：US09254384

    申请日：1999-03-02

    申请人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    发明人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    IPC分类号： C07D20982

    CPC分类号： C07D307/91 ,  A61K31/343 ,  A61K31/381 ,  C07C311/19 ,  C07C2603/18 ,  C07D333/76

    摘要： The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a method of treating diseases in which matrix melatoproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.

    摘要翻译： 本发明涉及使用具有式IIIO的二苯并呋喃磺酰胺衍生物的化合物抑制基质金属蛋白酶的方法，本发明涉及一种治疗涉及多发性硬化症，动脉粥样硬化斑块破裂，再狭窄的基质蛋白酶的疾病的方法 ，主动脉瘤，心力衰竭，牙周病，角膜溃疡，烧伤，褥疮性溃疡，慢性溃疡或创伤，癌症转移，肿瘤血管生成，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎性疾病。