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公开(公告)号：US07913425B2
公开(公告)日：2011-03-29
申请号：US12534680
申请日：2009-08-03
IPC分类号： A43B15/02
CPC分类号： A43C15/168 , A43B13/223 , A43C15/14
摘要： A convertible shoe having a shoe body and a shoe sole. An air channel formed in said shoe sole including pressurized air inlet and air exhaust. An elongated pocket or multiple individual pockets in the bottom of the shoe sole and along said air channel. A flexible wall portion between said air channel and pocket that expands into the pocket(s) upon pressurization of said air channel. A protrusion affixed to said flexible wall portion and which extends out of said pocket and into engagement with a support surface when said air channel is pressurized.
摘要翻译： 一种具有鞋身和鞋底的敞篷车。 形成在所述鞋底中的空气通道包括加压空气入口和排气。 鞋底底部和沿着空气通道的细长的口袋或多个单独的口袋。 所述空气通道和袋之间的柔性壁部分在所述空气通道加压时膨胀到所述袋中。 当所述空气通道被加压时，固定到所述柔性壁部分并且从所述袋延伸出并与支撑表面接合的突起。
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公开(公告)号：US07291237B2
公开(公告)日：2007-11-06
申请号：US11087711
申请日：2005-03-24
CPC分类号： B60C11/24 , Y10T152/10027
摘要： A tire in which a tire manufacturer has determined the tractive capacity at numerous levels of tread wear, the tire having at least one visual warning indicator located at a tread depth corresponding to a percentage loss of tractive capacity. Also, a method of making the tire and a method improving traffic safety through use of such a tire combined with educating the consumer as to proper use of the tire.
摘要翻译： 一种轮胎，其中轮胎制造商已经确定了多个胎面磨损级别的牵引能力，轮胎具有位于与牵引能力的百分比损失相对应的胎面深度处的至少一个视觉警告指示器。 此外，制造轮胎的方法以及通过使用这样的轮胎提高交通安全性的方法结合教育消费者来正确使用轮胎。
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公开(公告)号：US07179822B2
公开(公告)日：2007-02-20
申请号：US10634709
申请日：2003-08-05
IPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , A61K31/40 , A61K31/44 , A61P19/02
CPC分类号： C07D257/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D271/10 , C07D271/107 , C07D285/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D409/06 , C07D413/10 , C07D417/10 , C07D417/12
摘要： This invention provides compounds defined by Formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of treating osteo- and rheumatoid arthritis.
摘要翻译： 本发明提供由式I定义的化合物及其药学上可接受的盐，以及包含式I化合物或其药学上可接受的盐以及药学上可接受的载体，稀释剂或赋形剂的药物组合物。 本发明还提供了治疗骨关节炎和类风湿性关节炎的方法。
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4.发明授权公开(公告)号：US06634222B2
公开(公告)日：2003-10-21
申请号：US10053137
申请日：2002-01-17
IPC分类号： G01M1700
CPC分类号： B60C11/24 , Y10T152/10027
摘要： A four step process for removing vehicles from the public roadways having worn tires including (a) establishing a standard for end of life tire conditions, (b) converting the standard to relate correspondingly to tread wear, (c) providing a visual indication of end of life tread wear and (d) providing for inspection and vehicle disqualification where end of life tire wear is indicated.
摘要翻译： 从轮胎的公共道路上移除车辆的四步骤，包括：（a）建立轮胎寿命终止标准，（b）将标准转换成与胎面磨损相对应，（c）提供终点的视觉指示 的生活胎面磨损和（d）提供检查和车辆取消资格，其中指出寿命结束的轮胎磨损。
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公开(公告)号：US5646170A
公开(公告)日：1997-07-08
申请号：US433776
申请日：1995-05-03
申请人： Helen Tsenwhei Lee , Patrick Michael O'Brien , Joseph Armand Picard , Claude Forsey Purchase, Jr. , Bruce David Roth , Drago Robert Sliskovic , Andrew David White
发明人： Helen Tsenwhei Lee , Patrick Michael O'Brien , Joseph Armand Picard , Claude Forsey Purchase, Jr. , Bruce David Roth , Drago Robert Sliskovic , Andrew David White
IPC分类号： A61K31/41 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07D207/337 , C07D215/38 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D249/04 , C07D249/06 , C07D257/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/22 , C07D277/30 , C07D285/12 , C07D307/54 , C07D333/24 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04
CPC分类号： C07D231/12 , C07D233/56 , C07D249/04 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/10 , C07D277/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
摘要： Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R.sub.2 .dbd.R.sub.3 .dbd.H; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from one to 18 carbon atoms; R.sub.2 and R.sub.3 are hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl, substituted phenyl, a heteroaryl, or form a spiroalkyl group; X is a heteromonocyclic 5-membered ring containing one to four heteroatoms, said heteroatoms being nitrogen, oxygen or sulfur, and combination thereof; and R.sub.4 is a hydrocarbon group having from one to 20 carbon atoms are described as well as methods of their manufacture.
摘要翻译： 对于除了四唑之外的X，n = 2，然后R2 = R3 = H，具有式IMAImage的ACAT抑制活性的药学上有用的化合物，其中n为0,1或2。 R 1是苯基，取代的苯基，萘基，取代的萘基，杂芳基或具有1至18个碳原子的烃基; R2和R3是氢，卤素，羟基，烷基，烯基，环烷基，苯基，取代的苯基，杂芳基或形成螺烷基; X是含有一至四个杂原子的杂单环五元环，所述杂原子是氮，氧或硫，以及它们的组合; 并且描述了R4是具有1至20个碳原子的烃基以及它们的制备方法。
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公开(公告)号：US20100024250A1
公开(公告)日：2010-02-04
申请号：US12534680
申请日：2009-08-03
CPC分类号： A43C15/168 , A43B13/223 , A43C15/14
摘要： A convertible shoe having a shoe body and a shoe sole. An air channel formed in said shoe sole including pressurized air inlet and air exhaust. An elongated pocket or multiple individual pockets in the bottom of the shoe sole and along said air channel. A flexible wall portion between said air channel and pocket that expands into the pocket(s) upon pressurization of said air channel. A protrusion affixed to said flexible wall portion and which extends out of said pocket and into engagement with a support surface when said air channel is pressurized.
摘要翻译： 一种具有鞋身和鞋底的敞篷车。 形成在所述鞋底中的空气通道包括加压空气入口和排气。 鞋底底部和沿着空气通道的细长的口袋或多个单独的口袋。 所述空气通道和袋之间的柔性壁部分在所述空气通道加压时膨胀到所述袋中。 当所述空气通道被加压时，固定到所述柔性壁部分并且从所述袋延伸出并与支撑表面接合的突起。
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公开(公告)号：US20080161365A1
公开(公告)日：2008-07-03
申请号：US11718297
申请日：2005-12-05
IPC分类号： A61K31/44 , C07D213/81 , A61P19/02
CPC分类号： C07D213/81 , C07D213/56
摘要： This invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition; a method of treating a disease mediated by an MMP-13 enzyme in a mammal; and a therapeutic combination containing at least two pharmaceutically active components, wherein R1, Q, W1, W2, W2a, R3a, R3b, L1, and L2, the pharmaceutical composition, the method of treating, and the therapeutic combination are as defined in the specification.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐; 药物组合物; 治疗哺乳动物中由MMP-13酶介导的疾病的方法; 和含有至少两种药物活性成分的治疗组合，其中R 1，Q，W 1，W 2，W 2a R 3，R 3，R 3，L 1和L 2，药物组合物， 治疗方法和治疗组合如说明书中所定义。
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公开(公告)号：US06906092B2
公开(公告)日：2005-06-14
申请号：US10603677
申请日：2003-06-25
IPC分类号： A61K31/343 , A61K31/381 , A61P9/10 , A61P17/02 , A61P27/02 , C07C311/19 , C07D307/91 , C07D333/76 , A61K31/40
CPC分类号： C07D307/91 , A61K31/343 , A61K31/381 , C07C311/19 , C07C2603/18 , C07D333/76
摘要： The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.
摘要翻译： 本发明涉及使用具有式I的二苯并呋喃磺酰胺衍生物的化合物抑制基质金属蛋白酶的方法。更具体地，本发明涉及治疗涉及基质金属蛋白酶的疾病的方法，例如多发性硬化，动脉粥样硬化斑块破裂， 再狭窄，主动脉瘤，心力衰竭，牙周病，角膜溃疡，烧伤，褥疮性溃疡，慢性溃疡或创伤，癌转移，肿瘤血管生成，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎性疾病。
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公开(公告)号：US06881743B2
公开(公告)日：2005-04-19
申请号：US10071073
申请日：2002-02-08
申请人： Nicole Chantel Barvian , David Thomas Connor , Patrick Michael O'Brien , Daniel Fred Ortwine , William Chester Patt , Kevon Ray Shuler , Michael William Wilson
发明人： Nicole Chantel Barvian , David Thomas Connor , Patrick Michael O'Brien , Daniel Fred Ortwine , William Chester Patt , Kevon Ray Shuler , Michael William Wilson
IPC分类号： A61K20060101 , A61K31/44 , A61K31/4427 , A61P20060101 , A61P9/00 , A61P9/04 , A61P19/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D20060101 , C07D213/80 , C07D213/81 , C07D213/82 , C07D401/14 , C07D405/14 , C07D409/14 , C07D521/00 , A61K31/4412 , C07D405/12
CPC分类号： C07D213/80 , C07D213/81 , C07D213/82 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D405/14 , C07D409/14
摘要： Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, NO2, NR4R5, CN, or CF3, E is independently O or S; A and B independently are OR4 or NR4R5; R4 and R5 independently are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring containing carbon atoms and optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted, n is an integer of from 0 to 6.
摘要翻译： 选择性MMP-13抑制剂是下式的吡啶衍生物或其药学上可接受的盐，其中：R 1和R 2独立地是氢，卤素，羟基，C
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公开(公告)号：US06620835B2
公开(公告)日：2003-09-16
申请号：US10162518
申请日：2002-06-04
IPC分类号： A61K31381
CPC分类号： C07D307/91 , A61K31/343 , A61K31/381 , C07C311/19 , C07C2603/18 , C07D333/76
摘要： The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.
摘要翻译： 本发明涉及使用具有式IIIO的二苯并呋喃磺酰胺衍生物的化合物抑制基质金属蛋白酶的方法，本发明涉及治疗涉及基质金属蛋白酶的疾病的方法，例如多发性硬化，动脉粥样硬化斑块破裂，再狭窄 ，主动脉瘤，心力衰竭，牙周病，角膜溃疡，烧伤，褥疮性溃疡，慢性溃疡或创伤，癌症转移，肿瘤血管生成，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎性疾病。
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