发明授权
- 专利标题： Continuous process for the preparation of optically pure decahydroisoquinolinecarboxamide
- 专利标题（中）： 用于制备光学纯的十氢异喹啉甲酰胺的连续方法
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申请号： US09857566申请日： 2001-09-04
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公开(公告)号： US06586597B1公开(公告)日： 2003-07-01
- 发明人: Sang-Hoon Park , Byoung-Sung Kwak , Tae-Yun Kim , In-Woo Lee , Seung-Hoon Oh
- 申请人： Sang-Hoon Park , Byoung-Sung Kwak , Tae-Yun Kim , In-Woo Lee , Seung-Hoon Oh
- 优先权： KR1998-54898 19981214
- 主分类号： C07D21716
- IPC分类号： C07D21716
摘要：
The present invention relates to a continuous process for the preparation of [3S-(3&agr;, 4a&bgr;, 8a&bgr;)]-N-tert-butyl-decahydro-3-isoquinolinecarboxamide, an intermediate useful in the synthesis of compounds for the treatment of viral diseases, from the reduction of N-tert-butyl-1,2,3,4-tetrahydro-3(S)-isoquinolinecarboxamide with a noble metal catalyst supported on inorganic oxide carrier in a fixed bed reaction system, with a high optical yield.
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