Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity

发明授权

US06638526B1 Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity 失效

标题翻译：与环氧乙烷和环氧丙烷的共聚物缀合的多肽以降低变应原性

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专利标题： Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity
专利标题（中）： 与环氧乙烷和环氧丙烷的共聚物缀合的多肽以降低变应原性
申请号： US09338746

申请日： 1999-06-23
公开(公告)号： US06638526B1

公开(公告)日： 2003-10-28
发明人: Heinz-Josef Deussen , Arne Agerlin Olsen , Tine Muxoll Fatum , Erwin Ludo Roggen
申请人： Heinz-Josef Deussen , Arne Agerlin Olsen , Tine Muxoll Fatum , Erwin Ludo Roggen
优先权： DK199800809 19980623
主分类号： A23K116
IPC分类号： A23K116

Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity

摘要：

A polypeptide-polymer conjugate is prepared having one or more polymers covalently bound to a polypeptide. The polymer has the general formula; EOXPOY wherein EO is ethylene oxide, PO is propylene oxide, x=1−99%, y=1−99%, x+y=100%, and x and y are in a ratio range of 10:90 to 90:10, more preferably 40:60 to 60:40, or in a 50/50 ratio. The polymer, which can be a block polymer, typically has a molecular weight in a range of 100 to 100,000 daltons, and the polypeptide may contain 1 to 100 polymer molecules. Coupling the polypeptide, in particular enzymes, to the polymer reduces respiratory allergenicity of the polypeptide. Industrial compositions such as detergent compositions, personal care compositions, compositions for processing/treating textiles, and food and feed compositions containing the polypeptide-polymer conjugate have reduced respiratory allergenicity.

摘要（中）：

制备具有共价结合多肽的一种或多种聚合物的多肽 - 聚合物缀合物。该聚合物具有通式： EOXPOY，其中EO是环氧乙烷，PO是环氧丙烷，x = 1-99％，y = 1-99％，x + y = 100％，x和y的比例范围为10:90〜90:10 ，更优选为40:60〜60:40，或50/50的比例。可以是嵌段聚合物的聚合物通常具有100至100,000道尔顿范围内的分子量，并且该多肽可含有1至100个聚合物分子。将多肽特别是酶与聚合物结合降低了多肽的呼吸过敏原。工业组合物如洗涤剂组合物，个人护理组合物，用于加工/处理纺织品的组合物以及含有多肽 - 聚合物缀合物的食品和饲料组合物具有降低的呼吸过敏原性。

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