Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity
    1.
    发明授权
    Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity 失效
    与环氧乙烷和环氧丙烷的共聚物缀合的多肽以降低变应原性

    公开(公告)号:US06638526B1

    公开(公告)日:2003-10-28

    申请号:US09338746

    申请日:1999-06-23

    IPC分类号: A23K116

    摘要: A polypeptide-polymer conjugate is prepared having one or more polymers covalently bound to a polypeptide. The polymer has the general formula; EOXPOY wherein EO is ethylene oxide, PO is propylene oxide, x=1−99%, y=1−99%, x+y=100%, and x and y are in a ratio range of 10:90 to 90:10, more preferably 40:60 to 60:40, or in a 50/50 ratio. The polymer, which can be a block polymer, typically has a molecular weight in a range of 100 to 100,000 daltons, and the polypeptide may contain 1 to 100 polymer molecules. Coupling the polypeptide, in particular enzymes, to the polymer reduces respiratory allergenicity of the polypeptide. Industrial compositions such as detergent compositions, personal care compositions, compositions for processing/treating textiles, and food and feed compositions containing the polypeptide-polymer conjugate have reduced respiratory allergenicity.

    摘要翻译: 制备具有共价结合多肽的一种或多种聚合物的多肽 - 聚合物缀合物。 该聚合物具有通式: EOXPOY,其中EO是环氧乙烷,PO是环氧丙烷,x = 1-99%,y = 1-99%,x + y = 100%,x和y的比例范围为10:90〜90:10 ,更优选为40:60〜60:40,或50/50的比例。 可以是嵌段聚合物的聚合物通常具有100至100,000道尔顿范围内的分子量,并且该多肽可含有1至100个聚合物分子。 将多肽特别是酶与聚合物结合降低了多肽的呼吸过敏原。 工业组合物如洗涤剂组合物,个人护理组合物,用于加工/处理纺织品的组合物以及含有多肽 - 聚合物缀合物的食品和饲料组合物具有降低的呼吸过敏原性。