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1.发明授权Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity 失效与环氧乙烷和环氧丙烷的共聚物缀合的多肽以降低变应原性公开(公告)号：US06638526B1
公开(公告)日：2003-10-28
申请号：US09338746
申请日：1999-06-23
IPC分类号： A23K116
CPC分类号： C11D3/38636 , A61K8/64 , A61K8/86 , A61K2800/57 , A61Q5/02 , A61Q5/10 , A61Q5/12 , A61Q9/02 , A61Q19/10 , C07K2319/00 , C11D3/3707 , C11D3/38 , C11D3/38654 , C12N9/54 , Y10S530/815
摘要： A polypeptide-polymer conjugate is prepared having one or more polymers covalently bound to a polypeptide. The polymer has the general formula; EOXPOY wherein EO is ethylene oxide, PO is propylene oxide, x=1−99%, y=1−99%, x+y=100%, and x and y are in a ratio range of 10:90 to 90:10, more preferably 40:60 to 60:40, or in a 50/50 ratio. The polymer, which can be a block polymer, typically has a molecular weight in a range of 100 to 100,000 daltons, and the polypeptide may contain 1 to 100 polymer molecules. Coupling the polypeptide, in particular enzymes, to the polymer reduces respiratory allergenicity of the polypeptide. Industrial compositions such as detergent compositions, personal care compositions, compositions for processing/treating textiles, and food and feed compositions containing the polypeptide-polymer conjugate have reduced respiratory allergenicity.
摘要翻译： 制备具有共价结合多肽的一种或多种聚合物的多肽 - 聚合物缀合物。 该聚合物具有通式： EOXPOY，其中EO是环氧乙烷，PO是环氧丙烷，x = 1-99％，y = 1-99％，x + y = 100％，x和y的比例范围为10:90〜90:10 ，更优选为40:60〜60:40，或50/50的比例。 可以是嵌段聚合物的聚合物通常具有100至100,000道尔顿范围内的分子量，并且该多肽可含有1至100个聚合物分子。 将多肽特别是酶与聚合物结合降低了多肽的呼吸过敏原。 工业组合物如洗涤剂组合物，个人护理组合物，用于加工/处理纺织品的组合物以及含有多肽 - 聚合物缀合物的食品和饲料组合物具有降低的呼吸过敏原性。
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公开(公告)号：US06303752B1
公开(公告)日：2001-10-16
申请号：US09104623
申请日：1998-06-25
IPC分类号： C07K110
CPC分类号： A21D2/26 , A21D8/042 , A23C9/1206 , A23K20/10 , A23K20/147 , A23K20/163 , A23K20/189 , A23L3/3526 , A23L3/3571 , A23L29/06 , A61K8/66 , A61K8/86 , A61K2800/57 , A61K2800/70 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10 , A61Q5/12 , A61Q9/02 , A61Q19/00 , A61Q19/10 , C11D3/3719 , C11D3/386 , C11D3/38627 , C11D3/38654 , C11D3/38681 , C11D11/0023 , C12N9/54 , C12N9/96 , C12N11/08
摘要： The present invention relates to modified polypeptides with reduced respiratory allergenicity having polymeric molecules with a molecular weight from 100 up to 750 Da, coupled covalently to the parent polypeptide having a molecular weight from 5 to 100 kDa. The present invention also relates to industrial compositions comprising modified polypeptide with reduced respiratory allergenicity, skin care products, the use of modified polypeptides for reducing the allergenicity of industrial composition and products and finally a method for reducing the allergenicity of polypeptides.
摘要翻译： 本发明涉及具有降低的呼吸变应原性的修饰多肽，其具有分子量为100至750Da的聚合物分子，与分子量为5至100kDa的亲本多肽共价偶联。 本发明还涉及包含具有降低的呼吸过敏原性的修饰多肽，皮肤护理产品，修饰多肽用于降低工业组合物和产品的变应原性的用途的工业组合物，最后还涉及降低多肽过敏原性的方法。
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公开(公告)号：US06245901B1
公开(公告)日：2001-06-12
申请号：US09024532
申请日：1998-02-17
IPC分类号： C07K1113
摘要： The present invention relates to polypeptide-polymer conjugates having added and/or removed one or more attachment groups for coupling polymeric molecules on the surface of the polypeptide structure, a method for preparing polypeptide-polymer conjugates of the invention, the use of said conjugated for reducing the immunogenicity and allergenicity and compositions comprising said conjugate.
摘要翻译： 本发明涉及多肽 - 聚合物缀合物，其具有添加和/或除去一个或多个用于偶联多肽结构表面上的聚合物分子的连接基团，本发明的多肽 - 聚合物缀合物的制备方法，所述缀合物 降低免疫原性和变应原性以及包含所述缀合物的组合物。
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公开(公告)号：US06461849B1
公开(公告)日：2002-10-08
申请号：US09417359
申请日：1999-10-13
申请人： Arne Agerlin Olsen , Claus von der Osten , Kim Vilbour Andersen , Steffen Ernst , Erwin Ludo Roggen
发明人： Arne Agerlin Olsen , Claus von der Osten , Kim Vilbour Andersen , Steffen Ernst , Erwin Ludo Roggen
IPC分类号： C12N950
CPC分类号： C12N9/242 , A61K47/54 , A61K47/60 , A61K47/646 , C11D3/3719 , C11D3/38 , C12N9/54
摘要： The present invention relates to polypeptides with reduced immune response including reduced allergenicity having one or more amino acid residues being substituted with other amino acid residues and/or having coupled one or more polymeric molecules in the vicinity of the polypeptides metal binding site, a method for preparing modified polypeptides of the invention, the use of the polypeptide for reducing the immunogenicity and allergenicity and compositions comprising the polypeptide.
摘要翻译： 本发明涉及具有降低的免疫应答的多肽，包括具有一个或多个氨基酸残基被其它氨基酸残基取代的降低的变应原性和/或在多肽金属结合位点附近具有偶联的一个或多个聚合物分子的方法， 制备本发明的修饰多肽，多肽用于降低免疫原性和变应原性的用途以及包含该多肽的组合物。
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公开(公告)号：US06623950B1
公开(公告)日：2003-09-23
申请号：US09705185
申请日：2000-11-02
IPC分类号： C12N950
摘要： The present invention relates to polypeptide-polymer conjugates having added and/or removed one or more attachment groups for coupling polymeric molecules on the surface of the polypeptide structure, a method for preparing polypeptide-polymer conjugates of the invention, the use of said conjugates for reducing the immunogenicity and allergenicity and compositions comprising said conjugate.
摘要翻译： 本发明涉及多肽 - 聚合物缀合物，其添加和/或除去一个或多个用于偶联多肽结构表面上的聚合物分子的连接基团，本发明的多肽 - 聚合物缀合物的制备方法，所述缀合物用于 降低免疫原性和变应原性以及包含所述缀合物的组合物。
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公开(公告)号：US07226770B2
公开(公告)日：2007-06-05
申请号：US10258783
申请日：2001-04-30
申请人： Erwin Ludo Roggen
发明人： Erwin Ludo Roggen
CPC分类号： C12N9/54 , A21D2/267 , A21D8/042 , A61K39/00 , C07K1/047 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K14/001 , C07K16/40 , C07K16/4283 , C11D3/38627 , C11D3/38645 , C12N9/0061 , C12N9/20 , C12Y110/03002 , C12Y304/21062 , Y10S435/911
摘要： The properties of a fungal lipolytic enzyme can be altered by substituting amino acid residues corresponding to certain specified amino acid residues in the T. lanuginosus lipase. The altered property may be, e.g., an increased thermostability, an altered pH dependence, or an altered substrate specificity.
摘要翻译： 真菌脂肪分解酶的性质可以通过替换对应于丝氨酸假单胞菌脂肪酶中某些特定氨基酸残基的氨基酸残基来改变。 改变的性质可以是例如增加的热稳定性，改变的pH依赖性或改变的底物特异性。
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公开(公告)号：US20110045572A1
公开(公告)日：2011-02-24
申请号：US12699979
申请日：2010-02-04
CPC分类号： C12N9/54 , A21D2/267 , A21D8/042 , A61K39/00 , C07K1/047 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K14/001 , C07K16/40 , C07K16/4283 , C11D3/38627 , C11D3/38645 , C12N9/0061 , C12N9/20 , C12Y110/03002 , C12Y304/21062 , Y10S435/911
摘要： The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids situated within 5 Å from the epitope amino acids constituting the epitope sequence, changing one or more of the amino acids defining the epitope area of the parent protein by genetical engineering mutations of a DNA sequence encoding the parent protein, introducing the mutated DNA sequence into a suitable host, culturing said host and expressing the protein variant, and evaluating the immunogenicity of the protein variant using the parent protein as reference. The invention further relates to the protein variant and use thereof, as well as to a method for producing said protein variant.
摘要翻译： 本发明涉及选择与亲本蛋白相比具有改良的免疫原性的蛋白质变体的方法，其包括获得抗体结合肽序列的步骤，使用该序列来定位母体蛋白的3维结构上的表位序列，限定表位 包括位于构成表位序列的表位氨基酸5埃范围内的氨基酸，通过编码母体蛋白质的DNA序列的遗传工程突变改变限定母体蛋白表位区域的一个或多个氨基酸，引入突变的 DNA序列转化为合适的宿主，培养所述宿主并表达蛋白质变体，并使用亲本蛋白作为参考来评估蛋白质变体的免疫原性。 本发明还涉及蛋白质变体及其用途，以及生产所述蛋白质变体的方法。
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公开(公告)号：US20100279383A1
公开(公告)日：2010-11-04
申请号：US12831450
申请日：2010-07-07
申请人： Erwin Ludo Roggen , Nina Teeres Herne , Steffen Ernst , Carsten Andersen , Ninna Willestofte Berg
发明人： Erwin Ludo Roggen , Nina Teeres Herne , Steffen Ernst , Carsten Andersen , Ninna Willestofte Berg
IPC分类号： C12N9/54
摘要： The present invention relates to subtilase variants and subtilases with an altered immunogenicity, particularly subtilase variants and subtilases with a reduced allergenecity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products.
摘要翻译： 本发明涉及具有改变的免疫原性的枯草芽孢杆菌变体和减毒酶，特别是具有降低的变应原性的枯草芽孢杆菌变体和枯草芽孢杆菌素。 此外，本发明涉及所述脱羧酶变体和枯草芽孢杆菌的表达及其用途，例如洗涤剂和口腔护理产品。
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公开(公告)号：US20080254041A1
公开(公告)日：2008-10-16
申请号：US10571496
申请日：2004-09-10
IPC分类号： A61K39/395
CPC分类号： C07K16/00 , A61K38/00 , C07K2317/34
摘要： The present invention relates to a method for selecting one or more immunotherapeutic preparation having improved properties as a vaccine against a target antigen, said method comprising raising antibodies against a group of candidate preparations and selecting one or more preparations which produces antibodies having higher affinity against the target antigen than does anti-bodies raised against at least one other preparation from the group. More particularly it relates to the need to provide recombinant allergens (Bet V 1) for SIT which have been modified by protein engineering.
摘要翻译： 本发明涉及一种选择一种或多种具有改善作为针对靶抗原的疫苗的性质的免疫治疗制剂的方法，所述方法包括针对一组候选制剂产生抗体，并选择一种或多种制备产生对 目标抗原比针对来自该组的至少一种其它制剂产生的抗体的抗原。 更具体地说，涉及为蛋白质工程改造的用于SIT的重组变应原（Bet V 1）的需要。
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