Invention Grant
US06642261B2 N-(aryl/heteroarylacety) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds
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N-（芳基/杂芳基）氨基酸酯，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法
- Patent Title: N-(aryl/heteroarylacety) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds
- Patent Title (中): N-（芳基/杂芳基）氨基酸酯，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法
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Application No.: US09984834Application Date: 2001-10-31
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Publication No.: US06642261B2Publication Date: 2003-11-04
- Inventor: Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia
- Applicant: Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia
- Main IPC: A61K3144
- IPC: A61K3144
Abstract:
Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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