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公开(公告)号：US5484940A
公开(公告)日：1996-01-16
申请号：US345973
申请日：1994-11-28
IPC分类号： C07D403/06 , C07D403/14 , C07D403/08
CPC分类号： C07D403/06 , C07D403/14
摘要： This invention is directed to novel substituted 3-indolyl-5-pyrazolone compounds as well as intermediates useful in the preparation of such substituted 3-indolyl-5-pyrazolone compounds.
摘要翻译： 本发明涉及新的取代的3-吲哚基-5-吡唑啉酮化合物以及可用于制备这种取代的3-吲哚基-5-吡唑啉酮化合物的中间体。
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公开(公告)号：US07119085B2
公开(公告)日：2006-10-10
申请号：US09816876
申请日：2001-03-23
申请人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号： A61K31/55 , A61K31/535 , A61K31/35 , A61K31/34
CPC分类号： C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
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公开(公告)号：US07030239B2
公开(公告)日：2006-04-18
申请号：US10847819
申请日：2004-05-18
申请人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号： C07D237/00 , C07D237/02 , C07D237/26 , C07D237/28 , C07D487/00
CPC分类号： C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及可用于治疗阿尔茨海默氏病和其他类似疾病的式（XII）的取代的羟基亚乙基化合物。
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公开(公告)号：US06333351B1
公开(公告)日：2001-12-25
申请号：US09303655
申请日：1999-05-03
申请人： Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia
发明人： Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia
IPC分类号： C07C22906
CPC分类号： A61K31/198 , A61K31/223 , A61K31/277
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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公开(公告)号：US20090074746A1
公开(公告)日：2009-03-19
申请号：US12074696
申请日：2004-09-24
申请人： Lawrence Y. Fang , Roy Hom , Varghese John , Michel Maillard
发明人： Lawrence Y. Fang , Roy Hom , Varghese John , Michel Maillard
IPC分类号： A61K31/166 , C07C233/64 , A61P25/00 , C12N9/50 , A61K39/395 , A61K38/00 , C12N9/99 , A61P25/28
CPC分类号： C07D295/13 , C07C215/28 , C07C233/78 , C07C235/84 , C07C239/20 , C07C243/22 , C07C243/28 , C07C271/16 , C07C271/18 , C07C275/24 , C07C311/03 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/37 , C07C317/44 , C07C323/60 , C07D211/60 , C07D215/12 , C07D277/04 , C07D303/36 , C07D307/52 , C07D307/54 , C07D333/24
摘要： The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译： 本发明是用于治疗阿尔茨海默病和其他类似疾病的式（X）的取代胺。
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公开(公告)号：US20080058336A1
公开(公告)日：2008-03-06
申请号：US11548136
申请日：2006-10-10
申请人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人： Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号： A61K31/5375 , A61K31/164 , A61K31/192 , A61K31/195 , A61K31/215 , A61P43/00 , C12N9/99 , A61K31/221 , A61K31/341 , A61K31/421 , A61K31/445
CPC分类号： C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要： The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及可用于治疗阿尔茨海默氏病和其他类似疾病的式（XII）的取代的羟基亚乙基化合物。
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公开(公告)号：US07214715B2
公开(公告)日：2007-05-08
申请号：US09896139
申请日：2001-06-29
申请人： James P. Beck , Lawrence Y. Fang , John N. Freskos , Andrea Gailunas , Roy Hom , Barbara Jagodzinska , Varghese John , Michel Maillard , Shon R. Pulley , Ruth E. TenBrink
发明人： James P. Beck , Lawrence Y. Fang , John N. Freskos , Andrea Gailunas , Roy Hom , Barbara Jagodzinska , Varghese John , Michel Maillard , Shon R. Pulley , Ruth E. TenBrink
IPC分类号： A61K31/166 , C07D233/78
CPC分类号： C07D295/26 , C07C215/28 , C07C233/78 , C07C235/84 , C07C239/20 , C07C243/22 , C07C243/28 , C07C271/16 , C07C271/18 , C07C275/24 , C07C311/03 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/37 , C07C317/44 , C07C323/60 , C07D211/60 , C07D215/12 , C07D277/04 , C07D295/13 , C07D303/36 , C07D307/52 , C07D307/54 , C07D333/24 , Y02P20/55 , Y02P20/582
摘要： The present invention is substituted amines of formula (X) and of the formula (X′) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译： 本发明是用于治疗阿尔茨海默病和其他类似疾病的式（X）和式（X'）的取代胺。
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公开(公告)号：US07034182B2
公开(公告)日：2006-04-25
申请号：US09896874
申请日：2001-06-29
申请人： Lawrence Y. Fang , Varghese John
发明人： Lawrence Y. Fang , Varghese John
IPC分类号： C07C243/12 , A61K31/16
CPC分类号： C07D295/13 , C07C215/28 , C07C233/78 , C07C235/84 , C07C239/20 , C07C243/22 , C07C243/28 , C07C271/16 , C07C271/18 , C07C275/24 , C07C311/03 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/37 , C07C317/44 , C07C323/60 , C07D211/60 , C07D215/12 , C07D277/04 , C07D303/36 , C07D307/52 , C07D307/54 , C07D333/24
摘要： The present invention is substituted amines of formula (XV) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译： 本发明是用于治疗阿尔茨海默病和其他类似疾病的式（ⅩⅤ）的取代胺。
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9.发明授权N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds 失效N-（芳基/杂芳基乙酰基）氨基酸酯，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法公开(公告)号：US06767918B2
公开(公告)日：2004-07-27
申请号：US10314221
申请日：2002-12-09
申请人： Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia
发明人： Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia
IPC分类号： A61K3138
CPC分类号： A61K31/198 , A61K31/223 , A61K31/277
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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10.发明授权N-(aryl/heteroarylacety) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds 失效N-（芳基/杂芳基）氨基酸酯，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法公开(公告)号：US06642261B2
公开(公告)日：2003-11-04
申请号：US09984834
申请日：2001-10-31
申请人： Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia
发明人： Jing Wu , Eugene D. Thorsett , Jeffrey S. Nissen , Thomas E. Mabry , Lee H. Latimer , Varghese John , Lawrence Y. Fang , James E. Audia
IPC分类号： A61K3144
CPC分类号： A61K31/198 , A61K31/223 , A61K31/277
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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