发明授权
US06676940B2 Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation
失效
抑制内皮细胞和纤维蛋白原介导的炎症的方法和组合物
- 专利标题： Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation
- 专利标题（中）： 抑制内皮细胞和纤维蛋白原介导的炎症的方法和组合物
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申请号： US09912740申请日： 2001-07-24
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公开(公告)号： US06676940B2公开(公告)日： 2004-01-13
- 发明人: Dario C. Altieri , Lucia R. Languino , George B. Thornton
- 申请人： Dario C. Altieri , Lucia R. Languino , George B. Thornton
- 主分类号： A61K39395
- IPC分类号： A61K39395
摘要：
The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.
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