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24 条记录 (耗时 0.032 秒)

    Methods for inhibiting endothelial cell and fibrinogen mediated inflammation using fibrinogen specific antibodies
    2.
    发明授权
    Methods for inhibiting endothelial cell and fibrinogen mediated inflammation using fibrinogen specific antibodies 失效
    使用纤维蛋白原特异性抗体抑制内皮细胞和纤维蛋白原介导的炎症的方法

    公开(公告)号：US06737058B2

    公开(公告)日：2004-05-18

    申请号：US09912741

    申请日：2001-07-24

    申请人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    发明人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    IPC分类号： A61K39395

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/70525 ,  C07K14/75 ,  C07K16/2821 ,  C07K16/36 ,  C07K2317/34 ,  Y10S514/885

    摘要： The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.

    摘要翻译： 本发明考虑了含有能够以不依赖RGD的方式结合内皮细胞的纤维蛋白原同源物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还描述了含有能够以不依赖RGD的方式结合纤维蛋白原的ICAM-1同系物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还考虑了通过施用本发明的同源物来抑制患者内皮细胞和纤维蛋白原介导的炎症的方法。

    Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation
    3.
    发明授权
    Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation 失效
    抑制内皮细胞和纤维蛋白原介导的炎症的方法和组合物

    公开(公告)号：US06265549B1

    公开(公告)日：2001-07-24

    申请号：US09347877

    申请日：1999-07-06

    申请人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    发明人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    IPC分类号： C07K1600

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/70525 ,  C07K14/75 ,  C07K16/2821 ,  C07K16/36 ,  C07K2317/34 ,  Y10S514/885

    摘要： The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.

    摘要翻译： 本发明考虑了含有能够以不依赖RGD的方式结合内皮细胞的纤维蛋白原同源物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还描述了含有能够以不依赖RGD的方式结合纤维蛋白原的ICAM-1同系物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还考虑了通过施用本发明的同源物来抑制患者内皮细胞和纤维蛋白原介导的炎症的方法。

    Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation
    4.
    发明授权
    Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation 失效
    抑制内皮细胞和纤维蛋白原介导的炎症的方法和组合物

    公开(公告)号：US06676940B2

    公开(公告)日：2004-01-13

    申请号：US09912740

    申请日：2001-07-24

    申请人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    发明人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    IPC分类号： A61K39395

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/70525 ,  C07K14/75 ,  C07K16/2821 ,  C07K16/36 ,  C07K2317/34 ,  Y10S514/885

    摘要： The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.

    摘要翻译： 本发明考虑了含有能够以不依赖RGD的方式结合内皮细胞的纤维蛋白原同源物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还描述了含有能够以不依赖RGD的方式结合纤维蛋白原的ICAM-1同系物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还考虑了通过施用本发明的同源物来抑制患者内皮细胞和纤维蛋白原介导的炎症的方法。

    EPR-1 proteins, polypeptides, and nucleic acid molecules encoding same
    9.
    发明授权
    EPR-1 proteins, polypeptides, and nucleic acid molecules encoding same 失效
    EPR-1蛋白质，多肽和编码相同的核酸分子

    公开(公告)号：US06072028A

    公开(公告)日：2000-06-06

    申请号：US448722

    申请日：1995-05-25

    申请人： Dario C. Altieri

    发明人： Dario C. Altieri

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P37/00 ,  C07H21/04 ,  C07K14/575 ,  C07K14/705 ,  C07K14/745 ,  C07K16/28 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  C07K16/36

    CPC分类号： C07K14/575 ,  A61K39/395 ,  C07K14/705 ,  C07K14/745 ,  C07K16/28 ,  A61K38/00 ,  C07K2317/74 ,  Y10S436/813

    摘要： A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. The DNA and amino acid residue sequences of the receptor are also described. The invention also discloses methods, sequences and vectors useful in the purification and synthesis of cellular receptors of the present invention, which receptors are identified herein as Effector Cell Protease Receptor-1 (EPR-1). Antibody compositions capable of immunoreacting with the receptor or with polypeptides containing the identified amino acid residue sequences and related therapeutic and diagnostic protocols are also described, as are polypeptides, compositions and methods relating to the inhibition of T lymphocyte proliferation using the antibodies disclosed herein. The present invention also discloses polypeptides, antibodies and compositions capable of stimulating or co-stimulating lymphocyte proliferation.

    摘要翻译： 鉴定出与凝血因子V和VIII广泛同源但不完全相同的新一类细胞受体。 还描述了受体的DNA和氨基酸残基序列。 本发明还公开了可用于纯化和合成本发明的细胞受体的方法，序列和载体，其受体在本文中被鉴定为效应细胞蛋白酶受体-1（EPR-1）。 还描述了能够与受体或含有鉴定的氨基酸残基序列和相关治疗和诊断方案的多肽免疫反应的抗体组合物，以及使用本文公开的抗体抑制T淋巴细胞增殖的多肽，组合物和方法。 本发明还公开了能刺激或共刺激淋巴细胞增殖的多肽，抗体和组合物。