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10 条记录 (耗时 0.023 秒)

    Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation
    1.
    发明授权
    Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation 失效
    抑制内皮细胞和纤维蛋白原介导的炎症的方法和组合物

    公开(公告)号：US06265549B1

    公开(公告)日：2001-07-24

    申请号：US09347877

    申请日：1999-07-06

    申请人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    发明人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    IPC分类号： C07K1600

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/70525 ,  C07K14/75 ,  C07K16/2821 ,  C07K16/36 ,  C07K2317/34 ,  Y10S514/885

    摘要： The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.

    摘要翻译： 本发明考虑了含有能够以不依赖RGD的方式结合内皮细胞的纤维蛋白原同源物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还描述了含有能够以不依赖RGD的方式结合纤维蛋白原的ICAM-1同系物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还考虑了通过施用本发明的同源物来抑制患者内皮细胞和纤维蛋白原介导的炎症的方法。

    Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation
    5.
    发明授权
    Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation 失效
    抑制内皮细胞和纤维蛋白原介导的炎症的方法和组合物

    公开(公告)号：US06676940B2

    公开(公告)日：2004-01-13

    申请号：US09912740

    申请日：2001-07-24

    申请人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    发明人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    IPC分类号： A61K39395

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/70525 ,  C07K14/75 ,  C07K16/2821 ,  C07K16/36 ,  C07K2317/34 ,  Y10S514/885

    摘要： The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.

    摘要翻译： 本发明考虑了含有能够以不依赖RGD的方式结合内皮细胞的纤维蛋白原同源物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还描述了含有能够以不依赖RGD的方式结合纤维蛋白原的ICAM-1同系物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还考虑了通过施用本发明的同源物来抑制患者内皮细胞和纤维蛋白原介导的炎症的方法。

    BENZAZOCINE-RING COMPOUND INHIBITION OF TAU HYPERPHOSPHORYLATION
    7.
    发明申请
    BENZAZOCINE-RING COMPOUND INHIBITION OF TAU HYPERPHOSPHORYLATION 审中-公开
    苯并噻吩化合物抑制TAO高磷酸化

    公开(公告)号：US20140094482A1

    公开(公告)日：2014-04-03

    申请号：US13968078

    申请日：2013-08-15

    申请人： George B. Thornton ,  Hoau-Yan Wang ,  Lindsay Burns Barbier ,  Michael S. Zamloot

    发明人： George B. Thornton ,  Hoau-Yan Wang ,  Lindsay Burns Barbier ,  Michael S. Zamloot

    IPC分类号： A61K31/485 ,  C12N5/079

    CPC分类号： A61K31/485 ,  A61K31/135 ,  A61K31/435 ,  A61K31/438 ,  A61K31/44 ,  C12N5/0618

    摘要： A method of inhibiting hyperphosphorylation of the tau protein and/or a TLR4-mediated immune response is disclosed. The method contemplates administering to cells in recognized need thereof such as cells of the central nervous system a FLNA-binding effective amount of a FLNA-binding benzazocine-ring compound or a pharmaceutically acceptable salt thereof such as a) an opioid receptor antagonist compound or b) a mixed opioid receptor agonist and antagonist (agonist/antagonist) compound, c) an opioid receptor agonist compound or d) an enantiomer of an opioid receptor interacting compound, that binds to a pentapeptide of filamin A (FLNA) of SEQ ID NO: 1. The administered compound preferably contains at least four of the six pharmacophores of FIGS. 5-10.

    摘要翻译： 公开了抑制tau蛋白和/或TLR4介导的免疫应答的高度磷酸化的方法。 该方法考虑对其认识到需要的细胞给药，例如中枢神经系统的细胞，FLNA结合有效量的FLNA结合苯并吖嗪环化合物或其药学上可接受的盐，例如a）阿片受体拮抗剂化合物或b ）混合的阿片受体激动剂和拮抗剂（激动剂/拮抗剂）化合物，c）阿片受体激动剂化合物或d）与阿片样物质受体相互作用化合物的对映异构体，其结合SEQ ID NO： 施用的化合物优选含有图6和图6的六个药效团中的至少四个。 5-10。

    Methods for inhibiting endothelial cell and fibrinogen mediated inflammation using fibrinogen specific antibodies
    8.
    发明授权
    Methods for inhibiting endothelial cell and fibrinogen mediated inflammation using fibrinogen specific antibodies 失效
    使用纤维蛋白原特异性抗体抑制内皮细胞和纤维蛋白原介导的炎症的方法

    公开(公告)号：US06737058B2

    公开(公告)日：2004-05-18

    申请号：US09912741

    申请日：2001-07-24

    申请人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    发明人： Dario C. Altieri ,  Lucia R. Languino ,  George B. Thornton

    IPC分类号： A61K39395

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/70525 ,  C07K14/75 ,  C07K16/2821 ,  C07K16/36 ,  C07K2317/34 ,  Y10S514/885

    摘要： The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.

    摘要翻译： 本发明考虑了含有能够以不依赖RGD的方式结合内皮细胞的纤维蛋白原同源物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还描述了含有能够以不依赖RGD的方式结合纤维蛋白原的ICAM-1同系物的治疗组合物，其抑制纤维蛋白原与内皮细胞的结合。 还考虑了通过施用本发明的同源物来抑制患者内皮细胞和纤维蛋白原介导的炎症的方法。