发明授权
US06696420B1 Adenoviral vector with a deletion in the E1A coding region expressing a hetorologous protein
失效
使用编码HBV S抗原的缺陷性腺病毒在哺乳动物中诱导抗体的方法
- 专利标题： Adenoviral vector with a deletion in the E1A coding region expressing a hetorologous protein
- 专利标题（中）： 使用编码HBV S抗原的缺陷性腺病毒在哺乳动物中诱导抗体的方法
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申请号： US08093901申请日： 1993-07-20
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公开(公告)号： US06696420B1公开(公告)日： 2004-02-24
- 发明人: Michel Perricaudet , Annick Ballay , Massimo Levredo , Pierre Tiollais
- 申请人： Michel Perricaudet , Annick Ballay , Massimo Levredo , Pierre Tiollais
- 优先权： FR8417674 19841120
- 主分类号： A61K4800
- IPC分类号： A61K4800
摘要：
Recombinant DNA modified by a nucleotide sequence coding for a specific polypeptide sequence whose expression is sought, this recombinant DNA being appropriate to the transformation of eucaryotic cell lines, notably human or animal, the endogenous polymerases of which are susceptible of recognizing the adenovirus promoters. The DNA according to the invention is more particularly characterized by the fact that the said insertion nucleotide sequence is placed under the direct control of the early promoter of the E1A region of the genome of adenovirus.
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