- 专利标题： Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
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申请号： US08316765申请日： 1994-10-03
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公开(公告)号： US06706873B1公开(公告)日： 2004-03-16
- 发明人: Sergei A. Tsarev , Suzanne U. Emerson , Robert H. Purcell
- 申请人： Sergei A. Tsarev , Suzanne U. Emerson , Robert H. Purcell
- 主分类号： C07H2104
- IPC分类号： C07H2104
摘要：
A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
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