发明授权
- 专利标题： Recombinant anti-CCR2 antibodies and methods of use therefor
- 专利标题（中）： 重组抗CCR2抗体及其用途的方法
-
申请号： US09497625申请日： 2000-02-03
-
公开(公告)号： US06727349B1公开(公告)日： 2004-04-27
- 发明人: Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
- 申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
- 主分类号： C07K1600
- IPC分类号： C07K1600
摘要：
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
信息查询
