-
公开(公告)号:US20130071381A1
公开(公告)日:2013-03-21
申请号:US13528407
申请日:2012-06-20
申请人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号: C07K16/28
CPC分类号: C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
公开(公告)号:US20080241136A1
公开(公告)日:2008-10-02
申请号:US11924794
申请日:2007-10-26
申请人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号: A61K39/395
CPC分类号: C07K16/2866 , A61K2039/505 , C07K2317/76
摘要: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
公开(公告)号:US07402410B2
公开(公告)日:2008-07-22
申请号:US11511164
申请日:2006-08-28
申请人: Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
发明人: Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , José Saldanha , Mary M. Bendig
CPC分类号: C07K16/2839 , A61K38/00 , C07K14/70503 , C07K2317/24 , C07K2319/00
摘要: The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.
摘要翻译: 本发明涉及编码对α4β7整联蛋白具有结合特异性,编码人源化免疫球蛋白重链的分离的核酸和编码具有α4β7整联蛋白的结合特异性的人源化轻链的分离的核酸的分离的核酸。 本发明还涉及包含编码具有对α4β7具有结合特异性的人源化免疫球蛋白或其抗原结合片段的核苷酸序列的表达载体和宿主细胞。 本发明还涉及制备对α4β7整联蛋白具有结合特异性的人源化免疫球蛋白,人源化免疫球蛋白重链和人源化免疫球蛋白轻链的方法。
-
公开(公告)号:US08227211B2
公开(公告)日:2012-07-24
申请号:US12235765
申请日:2008-09-23
申请人: Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人: Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号: A61K39/395 , C12N15/13 , C07K16/00
CPC分类号: C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译: 本发明涉及与哺乳动物(例如人)CC趋化因子受体2(CCR2)或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法,以及在治疗,预防和诊断方法中使用抗体和片段。
-
公开(公告)号:US20080268536A1
公开(公告)日:2008-10-30
申请号:US11924091
申请日:2007-10-25
申请人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号: C12N5/06
CPC分类号: C07K16/2866 , A61K2039/505 , C07K2317/76
摘要: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译: 本发明涉及与哺乳动物(例如人)CC趋化因子受体2(CCR2)或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法,以及在治疗,预防和诊断方法中使用抗体和片段。
-
公开(公告)号:US06727349B1
公开(公告)日:2004-04-27
申请号:US09497625
申请日:2000-02-03
申请人: Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人: Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号: C07K1600
CPC分类号: C07K14/7158 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2319/00
摘要: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译: 本发明涉及与哺乳动物(例如人)CC趋化因子受体2(CCR2)或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法,以及在治疗,预防和诊断方法中使用抗体和片段。
-
公开(公告)号:US06696550B2
公开(公告)日:2004-02-24
申请号:US09840459
申请日:2001-04-23
申请人: Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人: Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号: C07K1600
CPC分类号: C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译: 本发明涉及与哺乳动物(例如人)CC趋化因子受体2(CCR2)或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法,以及在治疗,预防和诊断方法中使用抗体和片段。
-
公开(公告)号:US07566450B2
公开(公告)日:2009-07-28
申请号:US11924794
申请日:2007-10-26
申请人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号: A61K39/395
CPC分类号: C07K16/2866 , A61K2039/505 , C07K2317/76
摘要: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
9.
公开(公告)号:US20090011464A1
公开(公告)日:2009-01-08
申请号:US12214304
申请日:2008-06-18
申请人: Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , Jose Saldanha , Mary M. Bendig
发明人: Paul D. Ponath , Douglas J. Ringler , S. Tarran Jones , Walter Newman , Jose Saldanha , Mary M. Bendig
摘要: The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.
摘要翻译: 本发明涉及编码对α4β7整联蛋白具有结合特异性,编码人源化免疫球蛋白重链的分离的核酸和编码具有α4β7整联蛋白的结合特异性的人源化轻链的分离的核酸的分离的核酸。 本发明还涉及包含编码具有对α4β7具有结合特异性的人源化免疫球蛋白或其抗原结合片段的核苷酸序列的表达载体和宿主细胞。 本发明还涉及制备对α4β7整联蛋白具有结合特异性的人源化免疫球蛋白,人源化免疫球蛋白重链和人源化免疫球蛋白轻链的方法。
-
公开(公告)号:US20080241923A1
公开(公告)日:2008-10-02
申请号:US11924153
申请日:2007-10-25
申请人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人: Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号: C12N5/06
CPC分类号: C07K16/2866 , A61K2039/505 , C07K2317/76
摘要: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
-
-
-
-
-
-
-
-