-
公开(公告)号：US08926971B2
公开(公告)日：2015-01-06
申请号：US13528407
申请日：2012-06-20
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： C07K16/28 , C07K14/715 , A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
公开(公告)号：US20090191192A1
公开(公告)日：2009-07-30
申请号：US12235765
申请日：2008-09-23
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N1/21 , C12N1/15 , C12N1/19 , C12P21/00 , C12N5/00 , A61P31/12 , C07K16/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
公开(公告)号：US07473421B2
公开(公告)日：2009-01-06
申请号：US10766773
申请日：2004-01-27
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
CPC分类号： C07K14/7158 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
公开(公告)号：US08227211B2
公开(公告)日：2012-07-24
申请号：US12235765
申请日：2008-09-23
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： A61K39/395 , C12N15/13 , C07K16/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。
-
公开(公告)号：US06727349B1
公开(公告)日：2004-04-27
申请号：US09497625
申请日：2000-02-03
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： C07K1600
CPC分类号： C07K14/7158 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。
-
公开(公告)号：US06696550B2
公开(公告)日：2004-02-24
申请号：US09840459
申请日：2001-04-23
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： C07K1600
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。
-
公开(公告)号：US07442775B2
公开(公告)日：2008-10-28
申请号：US10766610
申请日：2004-01-27
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。
-
公开(公告)号：US20130071381A1
公开(公告)日：2013-03-21
申请号：US13528407
申请日：2012-06-20
申请人： Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
公开(公告)号：US20080241136A1
公开(公告)日：2008-10-02
申请号：US11924794
申请日：2007-10-26
申请人： Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/76
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
公开(公告)号：US07566450B2
公开(公告)日：2009-07-28
申请号：US11924794
申请日：2007-10-26
申请人： Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher J. Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/76
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.04 秒)
