发明授权
- 专利标题: PPAR delta activators
- 专利标题(中): PPARδ激活剂
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申请号: US10344496申请日: 2003-02-11
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公开(公告)号: US06787552B2公开(公告)日: 2004-09-07
- 发明人: Shogo Sakuma , Tsuyoshi Endo , Atsushi Tendo , Toshihiro Takahashi , Shinichi Yoshida , Kunio Kobayashi , Nobutaka Mochizuki , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
- 申请人: Shogo Sakuma , Tsuyoshi Endo , Atsushi Tendo , Toshihiro Takahashi , Shinichi Yoshida , Kunio Kobayashi , Nobutaka Mochizuki , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
- 优先权: JP2000-243596 20000811; JP2000-402893 20001228
- 主分类号: A61K31421
- IPC分类号: A61K31421
摘要:
Compounds of the general formula (I) or salts thereof and activators of PPAR&dgr; (peroxisome proliferator activated receptor &dgr;) containing the compounds or the salts as the active ingredient: wherein R1 and R2 each are hydrogen, C1-8 alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X1 and X2 are each a free valency, oxygen, S(O)p (wherein p is an integer of 0 to 2), C(═O), C(═O)NH, NHC(═O), CH═CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R3 and R4 are each optionally substituted C1-8 alkyl; and R8 is hydrogen or C1-8 alkyl, with the proviso that when X1 is a free valency, X2 is not O or S(O)p, while when X1 is C(═O)NH, X2 is not a free valency.
公开/授权文献
- US20040097739A1 Ppar delta activators 公开/授权日:2004-05-20