Invention Grant
- Patent Title: Stereoselective reduction of substituted acetophenone
- Patent Title (中): 取代苯乙酮的立体选择性还原
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Application No.: US10092263Application Date: 2002-03-06
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Publication No.: US06800477B2Publication Date: 2004-10-05
- Inventor: Ramesh Patel , Animesh Goswami , Linda N. Chu , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Mary Jo Donovan , K. David Mirfakhrae
- Applicant: Ramesh Patel , Animesh Goswami , Linda N. Chu , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Mary Jo Donovan , K. David Mirfakhrae
- Main IPC: C12P4100
- IPC: C12P4100
Abstract:
The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.
Public/Granted literature
- US20030068811A1 Stereoselective reduction of substituted acetophenone Public/Granted day:2003-04-10
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