公开(公告)号：US06800477B2

公开(公告)日：2004-10-05

申请号：US10092263

申请日：2002-03-06

申请人： Ramesh Patel ,  Animesh Goswami ,  Linda N. Chu ,  Venkata B. Nanduri ,  Steven L. Goldberg ,  Robert M. Johnston ,  Mary Jo Donovan ,  K. David Mirfakhrae

发明人： Ramesh Patel ,  Animesh Goswami ,  Linda N. Chu ,  Venkata B. Nanduri ,  Steven L. Goldberg ,  Robert M. Johnston ,  Mary Jo Donovan ,  K. David Mirfakhrae

IPC分类号： C12P4100

CPC分类号： C12P7/22 ,  Y10S435/911 ,  Y10S435/938

摘要： The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.

摘要翻译： 本发明涉及通过微生物还原相应的含有酮基的化合物来制备（S）-1-芳基乙醇的新的立体选择性方法。 （S）-1-芳基乙醇可用作合成作为可用于治疗阿尔茨海默病的γ-分泌酶的抑制剂的化合物的中间体。