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公开(公告)号：US07119188B2
公开(公告)日：2006-10-10
申请号：US10453418
申请日：2003-06-03
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants and fragments thereof, that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译： 本发明涉及分离或重组的N-苄氧羰基脱保护酶多肽及其变体和片段，其催化从苄氧羰基保护的氨基酸和醇中除去苄氧羰基。 还涉及编码N-苄氧羰基脱保护酶多肽及其变体及其片段的分离的核酸以及包含这些核酸的载体和宿主细胞。 本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用该多肽的方法。
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公开(公告)号：US06800477B2
公开(公告)日：2004-10-05
申请号：US10092263
申请日：2002-03-06
申请人： Ramesh Patel , Animesh Goswami , Linda N. Chu , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Mary Jo Donovan , K. David Mirfakhrae
发明人： Ramesh Patel , Animesh Goswami , Linda N. Chu , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Mary Jo Donovan , K. David Mirfakhrae
IPC分类号： C12P4100
CPC分类号： C12P7/22 , Y10S435/911 , Y10S435/938
摘要： The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.
摘要翻译： 本发明涉及通过微生物还原相应的含有酮基的化合物来制备（S）-1-芳基乙醇的新的立体选择性方法。 （S）-1-芳基乙醇可用作合成作为可用于治疗阿尔茨海默病的γ-分泌酶的抑制剂的化合物的中间体。
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公开(公告)号：US06261810B1
公开(公告)日：2001-07-17
申请号：US09386588
申请日：1999-08-31
申请人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , David A. Lust , Sushil K. Srivastava
发明人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , David A. Lust , Sushil K. Srivastava
IPC分类号： C12P1718
CPC分类号： C07K5/06139 , A61K38/00 , C07K14/8103 , C12N9/1096
摘要： The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
摘要翻译： 本发明涉及二肽单体的酶氧化脱氨过程，以制备可用于制备具有内肽酶和血管紧张素转化酶抑制活性的化合物的中间体。
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公开(公告)号：US07087418B2
公开(公告)日：2006-08-08
申请号：US10320300
申请日：2002-12-16
CPC分类号： C12N9/0004 , C12Q1/26 , G01N2333/04
摘要： This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.
摘要翻译： 本发明涉及催化甲酸氧化成二氧化碳并同时将烟酰胺腺嘌呤二核苷酸（NAD +）还原为还原形式（NADH）的重组巴斯德毕赤酵母甲酸脱氢酶（FDH）酶。 还涉及编码巴斯德毕赤酵母多肽的分离的核酸及其片段和变体，以及包含这些核酸的载体和宿主细胞。 进一步相关的是分离的重组巴斯德毕赤酵母FDH多肽及其片段和变体，以及特异性结合巴斯德毕赤酵母多肽，片段或变体的抗体。 本发明还涉及获得分离的巴斯德毕赤酵母FDH核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用巴斯德毕赤酵母FDH的方法。
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公开(公告)号：US06929935B2
公开(公告)日：2005-08-16
申请号：US10320104
申请日：2002-12-16
CPC分类号： C12N9/0004 , C12Q1/26 , C12Q1/32 , G01N2333/04
摘要： This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to G. oxydans 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated G. oxydans 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using G. oxydans 2-ketoreductase in various reactions for industrial or pharmaceutical applications.
摘要翻译： 本发明涉及可用于合成手性醇的新型氧化葡糖杆菌2-酮还原酶。 还涉及编码G.oxydans 2-酮还原酶的分离的核酸及其酶片段及其变体，以及包含这些核酸的载体和宿主细胞。 进一步相关的是分离的G.oxydans 2-酮还原酶多肽及其片段和变体，以及特异性结合G.oxydans 2-酮还原酶多肽，片段或变体的抗体。 本发明还涉及获得分离的G.oxydans 2-酮还原酶核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用G.oxydans 2-酮还原酶的方法。
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公开(公告)号：US06515170B1
公开(公告)日：2003-02-04
申请号：US09843226
申请日：2001-04-26
申请人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
发明人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
IPC分类号： C07C3200
CPC分类号： C07K5/06139 , A61K38/00 , C07K14/8103 , C12N9/1096
摘要： The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
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公开(公告)号：US07696328B2
公开(公告)日：2010-04-13
申请号：US12150544
申请日：2008-04-28
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译： 本发明涉及催化从苄氧羰基保护的氨基酸和醇中除去苄氧羰基的分离的或重组的N-苄氧羰基脱保护酶多肽。 还涉及编码其N-苄氧羰基脱保护酶多肽的分离的核酸，以及包含这些核酸的载体和宿主细胞。 本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用该多肽的方法。
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公开(公告)号：US20090104670A1
公开(公告)日：2009-04-23
申请号：US12150544
申请日：2008-04-28
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译： 本发明涉及催化从苄氧羰基保护的氨基酸和醇中除去苄氧羰基的分离的或重组的N-苄氧羰基脱保护酶多肽。 还涉及编码其N-苄氧羰基脱保护酶多肽的分离的核酸，以及包含这些核酸的载体和宿主细胞。 本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用该多肽的方法。
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公开(公告)号：US07416876B2
公开(公告)日：2008-08-26
申请号：US11502704
申请日：2006-08-10
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N-CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译： 本发明涉及分离或重组的N-CBZ脱保护酶多肽，其催化从CBZ保护的氨基酸和醇及其变体，修饰和片段中除去CBZ。 还涉及编码N-CBZ-脱保护酶多肽的分离的核酸及其变体，修饰和片段，以及包含这些核酸的载体和宿主细胞。 本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用多肽的方法。
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公开(公告)号：US06649387B2
公开(公告)日：2003-11-18
申请号：US09842987
申请日：2001-04-26
IPC分类号： C12N910
CPC分类号： C07K5/06139 , A61K38/00 , C07K14/8103 , C12N9/1096
摘要： The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
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