Invention Grant
- Patent Title: Chimeric antigen-enterotoxin mucosal immunogens
- Patent Title (中): 嵌合抗原 - 肠毒素粘膜免疫原
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Application No.: US09825105Application Date: 2001-04-03
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Publication No.: US06846488B2Publication Date: 2005-01-25
- Inventor: Michael W. Russell , Terry D. Connell
- Applicant: Michael W. Russell , Terry D. Connell
- Applicant Address: US AL Birmingham
- Assignee: The UAB Research Foundation
- Current Assignee: The UAB Research Foundation
- Current Assignee Address: US AL Birmingham
- Agent Benjamin Aaron Adler
- Main IPC: A61P37/04
- IPC: A61P37/04 ; C07K14/245 ; C07K14/28 ; C07K14/315 ; A61K39/00 ; A61K38/00 ; C12N15/74 ; C12P21/08
Abstract:
The present invention provides methods of inducing immune responses by recombinant antigen-enterotoxin chimeric mucosal immunogens that contain the A2/B subunits of cholera toxin or heat-labile type II toxins. These chimeric immunogens differentially enhance antibody secretion, cytokine production, as well as B7-dependent co-stimulation of T cells and CD40L expression on CD4+ T cells.
Public/Granted literature
- US20020004238A1 Chimeric antigen-enterotoxin mucosal immunogens Public/Granted day:2002-01-10
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