公开(公告)号：US06846488B2

公开(公告)日：2005-01-25

申请号：US09825105

申请日：2001-04-03

Applicant: Michael W. Russell ,  Terry D. Connell

Inventor： Michael W. Russell ,  Terry D. Connell

IPC: A61P37/04 ,  C07K14/245 ,  C07K14/28 ,  C07K14/315 ,  A61K39/00 ,  A61K38/00 ,  C12N15/74 ,  C12P21/08

CPC classification number: A61K39/092 ,  A61K2039/53 ,  A61K2039/541 ,  A61K2039/55544 ,  C07K14/245 ,  C07K14/28 ,  C07K14/315 ,  C07K2319/00

Abstract: The present invention provides methods of inducing immune responses by recombinant antigen-enterotoxin chimeric mucosal immunogens that contain the A2/B subunits of cholera toxin or heat-labile type II toxins. These chimeric immunogens differentially enhance antibody secretion, cytokine production, as well as B7-dependent co-stimulation of T cells and CD40L expression on CD4+ T cells.

Abstract translation: 本发明提供了通过重组抗原 - 肠毒素嵌合粘膜免疫原诱导免疫应答的方法，所述免疫原含有霍乱毒素或不稳定型II型毒素的A2 / B亚基。 这些嵌合免疫原差别增强抗体分泌，细胞因子产生，以及CD4 + T细胞上的B7依赖性共刺激和CD40L表达。

公开(公告)号：US07776338B2

公开(公告)日：2010-08-17

申请号：US12265516

申请日：2008-11-05

Applicant: Terry D. Connell ,  Michael W. Russell ,  Hesham Nawar ,  Sergio Arce

Inventor： Terry D. Connell ,  Michael W. Russell ,  Hesham Nawar ,  Sergio Arce

IPC: A61K39/02 ,  A61K39/00 ,  A61K39/385 ,  A61K39/108 ,  A61K45/00 ,  A61K39/116 ,  A01N37/18

CPC classification number: A61K39/39 ,  A61K45/06 ,  A61K2039/55544 ,  A61K2039/6037

Abstract: The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa(T34I) mutant is also described which exhibits a late onset adjuvant activity. These mutants are useful for enhancing immune response to antigens.

Abstract translation: 本发明描述了缺乏神经节苷脂结合活性的LT-IIa和LT-IIb肠毒素突变体的佐剂活性。 LT-IIb（T13I）突变体的佐剂活性与野生型LT-IIb的佐剂活性相当。 还描述了LT-IIa（T34I）突变体的佐剂活性，其表现出迟发性佐剂活性。 这些突变体可用于增强对抗原的免疫应答。

公开(公告)号：US20090136535A1

公开(公告)日：2009-05-28

申请号：US12265516

申请日：2008-11-05

Applicant: Terry D. Connell ,  Michael W. Russell ,  Hesham Nawar ,  Sergio Arce

Inventor： Terry D. Connell ,  Michael W. Russell ,  Hesham Nawar ,  Sergio Arce

IPC: A61K39/02

CPC classification number: A61K39/39 ,  A61K45/06 ,  A61K2039/55544 ,  A61K2039/6037

Abstract: The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa(T34I) mutant is also described which exhibits a late onset adjuvant activity. These mutants are useful for enhancing immune response to antigens.

Abstract translation: 本发明描述了缺乏神经节苷脂结合活性的LT-IIa和LT-IIb肠毒素突变体的佐剂活性。 LT-IIb（T13I）突变体的佐剂活性与野生型LT-IIb的佐剂活性相当。 还描述了LT-IIa（T34I）突变体的佐剂活性，其表现出迟发性佐剂活性。 这些突变体可用于增强对抗原的免疫应答。

公开(公告)号：US07455843B2

公开(公告)日：2008-11-25

申请号：US10950822

申请日：2004-09-27

Applicant: Terry D. Connell ,  Michael W. Russell ,  Hesham Nawar ,  Sergio Arce

Inventor： Terry D. Connell ,  Michael W. Russell ,  Hesham Nawar ,  Sergio Arce

IPC: A61K39/02 ,  A61K39/108 ,  A61K45/00 ,  A61K39/116 ,  A61K39/295 ,  A61K39/00 ,  A61K39/385 ,  A61K38/00

CPC classification number: A61K39/39 ,  A61K45/06 ,  A61K2039/55544 ,  A61K2039/6037

Abstract: The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa(T34I) mutant is also described which exhibits a late onset adjuvant activity. These mutants are useful for enhancing immune response to antigens.

Abstract translation: 本发明描述了缺乏神经节苷脂结合活性的LT-IIa和LT-IIb肠毒素突变体的佐剂活性。 LT-IIb（T13I）突变体的佐剂活性与野生型LT-IIb的辅助活性相当。 还描述了LT-IIa（T34I）突变体的佐剂活性，其表现出迟发性佐剂活性。 这些突变体可用于增强对抗原的免疫应答。