Invention Grant
US06849649B2 N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
失效
的N- phenpropylcyclopentyl取代的戊二酰胺衍生物作为中性内肽酶抑制剂
- Patent Title: N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
- Patent Title (中): 的N- phenpropylcyclopentyl取代的戊二酰胺衍生物作为中性内肽酶抑制剂
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Application No.: US10696021Application Date: 2003-10-28
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Publication No.: US06849649B2Publication Date: 2005-02-01
- Inventor: Stephen Challenger , Andrew Simon Cook , Adam Thomas Gillmore , Donald Stuart Middleton , David Cameron Pryde , Alan Stobie
- Applicant: Stephen Challenger , Andrew Simon Cook , Adam Thomas Gillmore , Donald Stuart Middleton , David Cameron Pryde , Alan Stobie
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent Peter C. Richardson; Gregg C. Benson; Martha G. Munchhof
- Priority: GB0107750 20010328; GB0113112 20010530; GB0120152 20010817
- Main IPC: C07C235/82
- IPC: C07C235/82 ; C07C255/60 ; C07C323/40 ; C07D213/40 ; C07D215/12 ; C07D231/56 ; C07D307/81 ; C07D311/74 ; C07D317/62 ; C07D319/18 ; A61K31/44 ; A01N43/32 ; A01N43/56 ; A61K31/335 ; A61K31/415

Abstract:
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, —NR2R3 or —NR4SO2R5; X is the linkage —(CH2)n— or —(CH2)q—O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.
Public/Granted literature
- US20040106611A1 N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase Public/Granted day:2004-06-03
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